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EC number: 203-603-9
CAS number: 108-65-6
this eye irritation study in rabbits, groups of 3 male and 3 female New
Zealand white rabbits (4-9 months) were instilled with 0.1 ml of
undiluted Methyl Proxitol Acetate (one eye only) into the lower
conjunctival sac and the lids held together for a few seconds to prevent
loss of material. The eyes were not washed. A visual assessment of eye
irritancy was made at 1 hour, 24, 48 and 72 hours and 7 days after
instillation, following the method of Draize and the scores so obtained
were assessed as per the EU/EEC criteria and the Kay and Calandra
technique. The instillation of undiluted Methyl Proxitol Acetate into
the conjunctival sac of one eye of each of the six rabbits resulted in
severe initial pain. The group mean 24, 48 and 72 hour scores were 1.1
for redness, 0.2 for chemosis and 0 for corneal opacity and iritic
effects. Under the conditions of the study, Methyl Proxitol Acetate is
not classified as an irritant
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