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EC number: 203-603-9
CAS number: 108-65-6
In this skin irritation study in rabbits,
groups of 3 male and 3 femalewhite rabbits (4-9 months) were dosed with
0.5 ml of undiluted Methyl Proxitol Acetate. The dorsal hair between the
shoulders and hind quaters was closely shorn with fine
electric clippers. A test site was selected and a 2 cm x 2 cm lint patch
with 0.5 ml of the test was applied to it. The patch and the surrounding
skin were covered by a single layer of gauze and held in place by means
of an elastic adhesive bandage. After 4 hours the wrapping and patch
were removed. The site was examined for erythema and edema and
observations were made 30 minutes after patch removal, 24, 48 and 72
hours and 7 days after application. The group mean scores were
calculated and compared to the scoring system (refer to attachments).
There were no skin reactions following the application of undiluted
Methyl Proxitol Acetate, consequently the group mean 24, 48 and 72 hour
erythema and edema scores were both zero. Under the conditions of the
study, Methyl Proxitol Acetate was classified as not irritating
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