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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Studies with regard to acute oral toxicity, acceptable for assessment, also peer-reviewed under Regulation 793/93.

Data source

Reference
Reference Type:
other: EU Risk Assessment Report (RAR)
Title:
Trichloroethylene
Author:
Rapporteur: United Kingdom, on behalf of the European Union
Year:
2004

Materials and methods

Test type:
other:

Test material

Constituent 1
Chemical structure
Reference substance name:
Trichloroethylene
EC Number:
201-167-4
EC Name:
Trichloroethylene
Cas Number:
79-01-6
Molecular formula:
C2HCl3
IUPAC Name:
1,1,2-trichloroethene
Constituent 2
Reference substance name:
trichloroethene
IUPAC Name:
trichloroethene

Test animals

Species:
other: guinea pig, rabbit
Strain:
not specified

Administration / exposure

Type of coverage:
other: occlusive & semiocclusive
Vehicle:
not specified

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
> 20 000
Based on:
other: rabbit

Applicant's summary and conclusion

Conclusions:
The LD50 value of trichloroethylene in rabbits when administered by the dermal route, using an occlusive dressing, has been reported as being greater than 29000 mg/kg body weight .
In another study, the LD50 value in the rabbit following a 24-hour exposure with a semi-occlusive dressing was reported to be > 20000 mg/kg.
No deaths occurred in guinea-pigs following dermal
application of 7800 mg/kg body weight of trichloroethylene using a similar method: the only sign of toxicity noted was reduced weight gain during the 35-day post-exposure observation period.