Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 225-464-3
CAS number: 4861-19-2
Table 1. Individual animal data.
Rabbit No. Sex
OP = Opacity, AR = Area involved
RED = Redness, CH = Chemosis, DI = Discharge
RE = small retractions in eyelids
PC = pupil contracted
LC = loss of corneal tissue
S = suppuration
DB = discharge of blood
The eye irritation potential of urea was determined in 3 Vienna White
rabbits. The substance was administered in a single application to the
right conjunctival sac of each rabbit; the substance was not washed out.
The degree of corneal opacity, iris irritation and conjunctival
irritation (redness, swelling and discharge) were scored at 1, 24, 48,
72 hours and 8 days after application. Well defined to severe redness
and slight to well defined swelling of the conjunctivae was seen in all
rabbits. Slight opacity of the cornea was seen in 2 rabbits at 24 hours
and all rabbits at 48 and 72 hours. Other signs observed included small
retractions in eyelids, contracted pupil and loss of corneal tissue.
Circumcorneal injection was observed in all rabbits at 24 hours and
remained in 1 rabbit at 48 hours. One rabbit (male) also exhibited
suppination and bloody discharge 48 hours after application. All signs
of irritation had disappeared 8 days after application. The test
substance can be classified as mildly irritating to eyes.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Sellel veebilehel kasutatakse küpsiseid, et tagada lehe parim kasutus.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again