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EC number: 225-464-3
CAS number: 4861-19-2
Skin irritation / corrosionUrea phosphate did show corrosivity in an in vitro skin corrosion test.0.5 mL of a 80% phosphoric acid solution was observed to be corrosive to rabbit skin after 24 hours of exposure. Eye irritation:No reliable data are available for the eye irritation endpoint. Nevertheless as the substance is skin corrosive and classified accordingly, the substance is as well considered as eye corrosive. This is as well in accordance with the results of the unreliable studies.
Urea phosphate will be dissociated into urea and phosphoric acid in
Skin irritation / corrosion:
An in vitro skin corrosion test with urea phosphate itself (comparable
to OECD 435 guideline and validated according to ECVAM), did show that
this substance passess a chemical barrier in approx. 17 minutes, which
shows it is a corrosive substance.
BASF (1980) studied the skin irritant/corrosive properties of phosphoric
acid on Vienna White rabbit skin (6 male rabbits tested according to
guideline 1500.41 in the Federal Register Vol. 38, No. 187, S. 26019
from 1973 -09 -27). 0.5 mL of an 80% solution was applied to the shaved
test sites (half of the test sites were abraded). After 24 hours of
exposure, observations were done at 24 and 72 hours and at 8 days post
dosing. The substance was observed to be corrosive to rabbit skin.
No evidence of skin irritation was seen in a
modern guideline study with urea.
Phosphoric acid is classified as a skin corrosive substance category 1B
(concentration > or = 25%) and an eye irritant (10% < or = concentration
< 25%) according to the CLP Regulation Annex VI, table 3.1 (EC
Regulation 1272/2008 on classification, labelling and packaging of
substances and mixtures). This
data supports the in vitro skin corrosivity as tested for urea phosphate
and supports the urea phosphate classification as corrosive. Therefore,
according to the REACH Regulation, in vitro testing for eye irritation
with this substance does not need to be conducted (column 2 adaptation,
Annex VII, section 8.2). In vivo testing can be waived according to the
REACH Regulation as phosphoric acid is classified as corrosive to the
skin and as an eye irritant (column 2 adaptation, Annex VIII, section
Urea was found to be a mild eye irritant in a
guideline-compliant study, but is not classified as such.
Based on the available data urea phosphate is
classified according to Directive 67/548/EC as C 'Corrosive', R34
'Causes burns' and
based on phosphoric acid with specific concentration limits (<10% = no
classification and ≥10%≤C<25% = R36/38).
In addition, the harmonized classification (Annex VI, Table 3.1) of the
CLP Regulation (EC) No 1272/2008 reports that phosphoric acid is a skin
irritant substance category 1B, H314 'Causes severe skin burns and eye
damage' at following concentration limits: (<10% = no classification and ≥10%≤C<25%
= SKin cat. 2 H315).
According to the CLP Regulation (EC) 1272/2008 (Annex VI, Table 3.1),
phosphoric acid is considered as an eye irritant substance category 2,
H319 'Causes serious eye irritation' with a concentration limit of ≥10%≤C<25%.
These concentration limits are also taken over by urea phosphate
based on the corrosivity as shown fort he substance itself in an in
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