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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

A valid skin irritation/corrosion study according OECD 404 and a valid eye irritation study according OECD 405 are available.

Key value for chemical safety assessment

Skin irritation / corrosion

Link to relevant study records
Reference
Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: GLP guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
Principles of method if other than guideline:
500 mg dimethyl propylphosphonate were semiocclusively applied once to the intact skin of 3 female adult New Zealand White rabbit (3-4 kg) for an exposure period of 24 hours. Evaluation of skin irritation was made until day 14 according to DRAIZE.
GLP compliance:
yes
Species:
rabbit
Strain:
New Zealand White
Type of coverage:
semiocclusive
Preparation of test site:
clipped
Vehicle:
unchanged (no vehicle)
Controls:
not required
Duration of treatment / exposure:
4 hours
Observation period:
14 days
Number of animals:
3 animals
Irritation parameter:
erythema score
Basis:
animal #1
Time point:
24/48/72 h
Score:
1
Max. score:
1
Reversibility:
not fully reversible within: 14d
Irritation parameter:
erythema score
Basis:
animal #2
Time point:
24/48/72 h
Score:
1
Max. score:
1
Reversibility:
fully reversible within: 7d
Irritation parameter:
erythema score
Basis:
animal #3
Time point:
24/48/72 h
Score:
0 - 1
Max. score:
1
Reversibility:
fully reversible within: 24h
Irritation parameter:
erythema score
Basis:
mean
Time point:
other: 24, 48, and 72 hours
Score:
0.66
Max. score:
4
Reversibility:
fully reversible within: 7 days
Remarks on result:
other: erythema was fully reversible in 2 of 3 animals
Irritation parameter:
edema score
Basis:
mean
Time point:
24/48/72 h
Max. score:
0
Remarks on result:
other: No edema was seen at any animal at any time point (1h - 14d) after 4 h of exposure
Other effects:
no other effects found

Dimethyl propylphosphonate was 'slightly irritating to the skin' (exposure period: 4 hrs).

Very slight, barely perceptible erythematous reactions were observed in all three animals. In one animal signs were evident only 1 hour post administration and in the other animals up to and at 72 hours and 14 days, respectively.

Interpretation of results:
GHS criteria not met
Executive summary:

Dimethyl propylphosphonate (500 mg) was semiocclusively applied once to the intact skin of 3 female adult New Zealand White rabbit (3-4 kg) for an exposure period of 4 hours. Evaluation of skin irritation was made until day 14 according to Draize.

Dimethyl propylphosphonate was 'slightly irritating to the skin' (exposure period: 4 hrs).

Very slight, barely perceptible erythematous reactions were observed in all three animals. In one animal signs were evident only 1 hour post administration and in the other animals up to and at 72 hours and 14 days, respectively. Erythema score = 0.66, edema score = 0.

Therefore a classification is not justified.

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not irritating)

Eye irritation

Link to relevant study records
Reference
Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: GLP guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 405 (Acute Eye Irritation / Corrosion)
Principles of method if other than guideline:
A dose of 100 µl dimethyl propylphosphonate was placed into the conjunctival sac of one eye of 3 female adult New Zealand White rabbits (3-4 kg) for an exposure period of 24 hours. Then the treated eyes were rinsed with normal saline. The contralateral eye remained untreated and served as a control. The eyes were examined and the grade of ocular reaction was recorded up to day 21 according to DRAIZE.
GLP compliance:
yes
Species:
rabbit
Strain:
New Zealand White
Vehicle:
unchanged (no vehicle)
Controls:
not required
Duration of treatment / exposure:
24 hours
Observation period (in vivo):
14 days
Number of animals or in vitro replicates:
3 animals
Irritation parameter:
cornea opacity score
Basis:
mean
Time point:
other: 24, 48, and 72 h
Score:
1
Max. score:
4
Reversibility:
fully reversible within: 21 d
Irritation parameter:
iris score
Basis:
mean
Time point:
other: 24, 48, and 72 h
Score:
0.33
Max. score:
2
Reversibility:
fully reversible within: 7 d
Irritation parameter:
conjunctivae score
Basis:
mean
Time point:
other: 24, 48, and 72 h
Score:
1.55
Max. score:
3
Reversibility:
fully reversible within: 21 d
Irritation parameter:
chemosis score
Basis:
mean
Time point:
other: 24, 48, and 72 h
Score:
1.44
Max. score:
4
Reversibility:
fully reversible within: 21 d
Other effects:
no other effects

Dimethyl propylphosphonate was 'slightly irritating to the eye' (exposure period: 24 hrs).

Reactions of the mucous membranes and cornea were observed in all three animals. The iris was also transiently affected in all three animals, but at different times. Discharge was observed in all three animals. Signs proved to be fully reversible within 21 days.

Executive summary:

A dose of 100 µl dimethyl propylphosphonate was placed into the conjunctival sac of one eye of 3 female adult New Zealand White rabbits (3-4 kg) for an exposure period of 24 hours. Then the treated eyes were rinsed with normal saline. The contralateral eye remained untreated and served as a control. The eyes were examined and the grade of ocular reaction was recorded up to day 21 according to Draize.


Dimethyl propylphosphonate was 'slightly irritating to the eye' (exposure period: 24 hrs).


Reactions of the mucous membranes and cornea were observed in all three animals. The iris was also transiently affected in all three animals, but at different times. Discharge was observed in all three animals. Signs proved to be fully reversible within 21 days.


The findings indicates that dimethyl propylphosphonate may be considered as slight irritating to the eyes. According GHS a classification as Eye Irrit. 2; H 319 is appropritate due to a cornea score = 1.

Endpoint conclusion
Endpoint conclusion:
adverse effect observed (irritating)

Respiratory irritation

Endpoint conclusion
Endpoint conclusion:
no study available

Additional information

In the skin irritation/corrosion study dimethyl propylphosphonate was 'slightly irritating to the skin' (exposure period: 4 hrs).

Very slight, barely perceptible erythematous reactions were observed in all three animals. In one animal signs were evident only 1 hour post administration and in the other animals up to and at 72 hours and 14 days, respectively. Mean scores at 24, 48, and 73 hours: Erythema score = 0.66, edema score = 0.

In the eye irritation study dimethyl propylphosphonate was 'slightly irritating to the eye' (exposure period: 24 hrs).

Reactions of the mucous membranes and cornea were observed in all three animals. The iris was also transiently affected in all three animals, but at different times. Discharge was observed in all three animals. Signs proved to be fully reversible within 21 days. Mean scores at 24, 48, and 72 hours: Cornea score = 1, iris score = 0.33, conjunctiva score = 1.55, chemosis score = 1.44)


Justification for selection of skin irritation / corrosion endpoint:
Only available study

Justification for selection of eye irritation endpoint:
Only available study

Effects on eye irritation: slightly irritating

Justification for classification or non-classification

The findings indicates that dimethyl propylphosphonate may be considered as slight irritating to the eyes. According to GHS a classification as Eye Irrit. 2; H 319 is appropriate due to a mean cornea score = 1at 24, 48, and 72 hours.