Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 242-555-3 | CAS number: 18755-43-6
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 012
- Report date:
- 2012
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- Principles of method if other than guideline:
- One group of 3 male and 3 female Wistar rats was nose-only exposed to dimethyl propylphosphonate (DMPP) at an actual aerosol concentration of 5788 mg/m³ for 4 hours. The aerosol was generated neat without any vehicle. The animals were observed for mortality, weight and clinical signs through day 14. A gross necropsy was performed.
- GLP compliance:
- yes
- Test type:
- standard acute method
Test material
- Reference substance name:
- Dimethyl propylphosphonate
- EC Number:
- 242-555-3
- EC Name:
- Dimethyl propylphosphonate
- Cas Number:
- 18755-43-6
- Molecular formula:
- C5H13O3P
- IUPAC Name:
- dimethyl propylphosphonate
- Test material form:
- other: liquid
- Details on test material:
- - Purity: 97%
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
Administration / exposure
- Route of administration:
- inhalation: aerosol
- Type of inhalation exposure:
- nose only
- Vehicle:
- air
- Analytical verification of test atmosphere concentrations:
- yes
- Duration of exposure:
- 4 h
- Concentrations:
- 5788 mg/m³
- No. of animals per sex per dose:
- control group: 5 male and 5 female rats
test group: 3 male and 3 female rats - Control animals:
- yes
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- > 5 788 mg/m³ air
- Based on:
- test mat.
- Exp. duration:
- 4 h
Any other information on results incl. tables
The maximum tested concentration was tolerated without mortality.
The following clinical signs were observed: bradypnea, labored breathing patterns, piloerection, motility reduced, atony, high-legged gait; lurching, hypothermia, decreased reflexes, and transient decrease in body weights. The lead pathodiagnostic effects were
suggestive of mild and rapidly reversible portal of entry-related effects (irregular and labored breathing patterns which were observed up to the first postexposure day).
Gross necropsy was unobtrusive.
The respirability of the aerosol was adequate to achieve the objective of study, i.e. the average mass median aerodynamic diameter (MMAD) was 4.6 µm, the average geometric standard deviation (GSD) was 1.8. Measures were made to maximize the respirability of aerosol; however, at the expense of the actual concentration. Due to the marginal evidence of mild upper respiratory tract irritation, further exposure at lower but more respirable aerosol does not seem to be justified scientifically nor on animal welfare reasons.
In summary, the aerosolized test substance (liquid aerosol) proved to have a low acute inhalation toxicity in rats.
Applicant's summary and conclusion
- Executive summary:
One group of 3 male and 3 female wistar rats was nose-only exposed to dimethyl propylphosphonate (DMPP) at an actual aerosol concentration of 5788 mg/m³ for 4 hours. The aerosol was generated neat without any vehicle. The animals were observed for mortality, weight and clinical signs through day 14. A gross necropsy was performed.
The maximum tested concentration was tolerated without mortality.
The following clinical signs were observed: bradypnea, labored breathing patterns, piloerection, motility reduced, atony, high-legged gait; lurching, hypothermia, decreased reflexes, and transient decrease in body weights. The lead pathodiagnostic effects were
suggestive of mild and rapidly reversible portal of entry-related effects (irregular and labored breathing patterns which were observed up to the first postexposure day). Gross necropsy was unobtrusive.
The acute LC50 (aerosol) of dimethyl propylphosphonate is > 5788 mg/m³ in male and female rats.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
