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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: GLP guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1993
Report date:
1993

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
Principles of method if other than guideline:
Five male and five female Wistar rats (176-188 g) received a single dose of 2000 mg/kg bw of dimethyl propylphophonate per gavage. The animals were observed for mortality, body weights and clinical signs through day 14. A gross necropsy was performed on animals sacrificed at the end of the 14 days observation period.
GLP compliance:
yes
Test type:
standard acute method

Test material

Constituent 1
Chemical structure
Reference substance name:
Dimethyl propylphosphonate
EC Number:
242-555-3
EC Name:
Dimethyl propylphosphonate
Cas Number:
18755-43-6
Molecular formula:
C5H13O3P
IUPAC Name:
dimethyl propylphosphonate
Test material form:
not specified
Details on test material:
content: 98.7%

Test animals

Species:
rat
Strain:
Wistar
Sex:
male/female

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
water
Doses:
2000 mg/kg bw
No. of animals per sex per dose:
5 male and 5 female animals/dose
Control animals:
not specified

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 2 000 mg/kg bw
Based on:
test mat.

Any other information on results incl. tables

A dose of 2000 mg/kg bw caused a staggared gait, sedation, paresis of the hind limbs, ruffle fur, chromodacryorrhoe, haggard flanks, and crouch position.

Body weight gain was not influenced by male rats. The surviving female rats revealed a weight loss during the first observation week and one animal of both weeks.

One female rat died 3 days after the application of 2000 mg/kg bw of dimethyl propylphosphonate. The bladder was filled with blood and the intestines were filled with faces of hard consiscence.

One female rat killed after 14 days revealed a reddened intestine mucosa. All other animals were without finding at the gross necropsy.

Applicant's summary and conclusion

Executive summary:

Five male and five female Wistar rats (176-188 g) received a single dose of 2000 mg/kg bw of dimethyl propylphosphonate

per gavage. The animals were observed for mortality, body weights and clinical signs through day 14. A gross necropsy was performed on animals sacrificed at the end of the 14 days observation period.

A dose of 2000 mg/kg bw caused a staggared gait, sedation, paresis of the hind limbs, ruffle fur, chromodacryorrhoe, haggard flanks, and crouch position. One female rat died 3 days after the application of 2000 mg/kg bw of dimethyl propylphosphonate.

The LD50 is > 2000 mg/kg bw (male and female rats) and was not exactly determined.