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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Ecotoxicological information

Short-term toxicity to aquatic invertebrates

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Administrative data

Link to relevant study record(s)

Reference
Endpoint:
short-term toxicity to aquatic invertebrates
Type of information:
(Q)SAR
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
Remarks:
The scientific validity of the (Q)SAR model has been established in accordance with the OECD Principles for (Q)SAR Model Validation.
Principles of method if other than guideline:
ECOSAR v1.11
QMRF and QPRF are attached in IUCLID
GLP compliance:
not specified
Test organisms (species):
Daphnia magna
Duration:
48 h
Dose descriptor:
LC50
Effect conc.:
578 000 mg/L
Basis for effect:
mortality
Remarks on result:
other: (using the estimated KOWWIN LogKow of -2.56)

Supporting documentation is provided in the attached QPRF and QMRF.

Validity criteria fulfilled:
yes
Conclusions:
48-hr LC50: 5.78E+05 mg/L
Executive summary:

The ECOSAR 48-hr LC50 for Daphnia magna was predicted to be 5.78E+05 mg/L.

 

The neutral organics model for 48-hr Daphnia magna as housed within the ECOSAR v1.11 is a valid model in accordance with the OECD principles. The model relies upon KOWWIN v1.68 for its LogKow estimates. KOWWIN v1.68 has been evaluated previously and is described in a separate QMRF. The test substance is a general narcotic and its MW and LogKow values lie within the boundaries of the training set. Thus, the test substance satisfies the applicability domain requirement to a sufficient extent. Related analogues from within the training set indicate that the test substance is likely to be conservatively predicted. Adequate documentation has been provided by way of the QPRF, the associated QMRF ‘ECOSAR Neutral Organics Daphnid 48-h LC50’ and that of KOWWIN v1.68.

Description of key information

Key value for chemical safety assessment

Fresh water invertebrates

Fresh water invertebrates
Effect concentration:
578 000 mg/L

Additional information