Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 700-729-0
CAS number: 1369500-14-0
Local Dermal Signs
Local dermal signs (max grade)
1 / M
2 / F
4 / M
5 / M
6 / M
7 / F
8 / F
9 / F
10 / F
Acute dermal toxicity was assessed in a valid GLP study according to
OECD TG 402.
5 male and 5 female RccHan:WIST (SPF) rats were treated with the test
item at a dose level of 2000 mg/kg by dermal application. The test item
was applied by weight as supplied by the Sponsor. For better dermal
contact, the test item was moistened with purified water before
application. All animals were examined for clinical signs before
treatment, once within the first 30 minutes and approximately 1, 2, 3
and 5 hours after treatment on test day 1 and once daily during test
days 2 to 15. Local dermal signs were assessed once daily from test day
2 to 15. Mortality was assessed before treatment, once within the first
30 minutes and approximately 1, 2, 3 and 5 hours after treatment on test
day 1 (with the clinical signs) and twice daily during test days 2 to15.
Body weights were recorded on test day 1 (prior to administration) and
on test days 8 and 15. All animals were examined macroscopically after
being sacrificed at the end of the study.
No deaths occurred during the course of the study and no clinical signs
were observed. Four males and one female showed focal crusts after test
item application lasting for a minimum of 2 and a maximum of 13 days.
Brown discoloration of the skin was observed in all animals for a
minimum of 7 days after test item application and lasted up to the end
of the observation period in 3 males and 3 females. One female slightly
lost body weight in the second week after treatment (2%). The body
weights of the other animals were within the range commonly recorded for
this strain and age. No macroscopic findings were recorded at necropsy.
The median lethal dose of the test item after single dermal
administration to rats of both sexes, observed over a period of 14 days,
is greater than 2000 mg/kg body weight.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Sellel veebilehel kasutatakse küpsiseid, et tagada lehe parim kasutus.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again