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EC number: 226-394-6
CAS number: 5392-40-5
testing was performed in groups of male mice or rats to detect
short-term effects occurring within up to 60 min after intraperitoneal
or oral exposure. In mice, intraperitoneal doses ranged from 5-200 mg/kg
bw and oral doses were 50 or 100 mg/kg bw. Rats were exposed to a single
dose of 100 mg/kg bw, either by intraperitoneal or oral application. The
tests included observation of behaviour
in the open field test, rota rod performance, spontaneous motor
activity, and pentobarbital sleeping time,
covering endpoints as locomotor activity, muscle relaxation, anxiolytic
activity, and barbiturate induced sleeping behaviour.
mice, a central nervous depressant effect of citral was indicated after
intraperitoneal application starting at 50 mg/kg bw for spontaneous
motor activity and in the elevated plus maze test (Carlini
1986; Do Vale 2002),
but no effects were found after oral application up to the high dose of
100 mg/kg bw (Carlini
intraperitioneal application of 100 mg/kg citral in rats resulted in central
nervous depressant effects but
no effects were found after oral application of this dose to rats
In summary, after oral application no
neurological effects were found up to the highest tested dose (100 mg/kg
bw) , both in mice and in rats.
application represents a mode of exposure which is not relevant for
human exposure. The dose is delivered into the body independent of
absorption from the gastrointestinal tract and circumventing first-pass
metabolism in the liver. Consequently, the intraperitoneal effects observed
are not relevant for human risk assessment.
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