Registration Dossier
Registration Dossier
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EC number: 700-352-1 | CAS number: 62756-44-9
Eye irritation
Administrative data
- Endpoint:
- eye irritation
- Remarks:
- in vitro
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: recent test according validated method
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 008
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- EU Method B.5 (Acute Toxicity: Eye Irritation / Corrosion)
- Version / remarks:
- Draize eye test
- Principles of method if other than guideline:
- Method described in the French order of november 29, 1996, published in the Offical Journal of the French Republic of december 26, 1996.
- GLP compliance:
- yes
Test material
- Reference substance name:
- (pyridin-3-yl)methanol hydrofluoride
- EC Number:
- 700-352-1
- Cas Number:
- 62756-44-9
- Molecular formula:
- C6H8FNO
- IUPAC Name:
- (pyridin-3-yl)methanol hydrofluoride
Constituent 1
Test animals / tissue source
- Species:
- other: embryonic hen's egg chorioallantoic membrane
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- yes
- Duration of treatment / exposure:
- 20 seconds
- Observation period (in vivo):
- 5 minutes
- Number of animals or in vitro replicates:
- 4
Results and discussion
In vivo
Results
- Irritation parameter:
- other: Mean score
- Basis:
- mean
- Time point:
- other: < 30sec
- Score:
- 12
- Max. score:
- 12
- Reversibility:
- not specified
- Irritant / corrosive response data:
- hyperhemia, haemorrhage
Applicant's summary and conclusion
- Interpretation of results:
- highly irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: OECD GHS
- Conclusions:
- risk of serious damage to eyes
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