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EC number: 202-436-9
CAS number: 95-63-6
QSAR calculation gives an estimates 96hr EC50 for algae of 2.356 mg/l.
algal toxicity test is not available for 1, 2, 4-trimethylbenzene. In
the absence of measured data the use of a QSAR to predict the
ecotoxicity of 1, 2, 4-trimethylbenzene is an appropriate technique to
use when assessing whether this substance would meet the criteria for
PBT and potential classification. The ECOSAR model is a reliable and
appropriate QSAR model to apply to 1, 2, 4-trimethylbenzene as it is
based on a related chemical dataset that calculates the toxicity of
neutral organic hydrocarbons whose mode of action is non-polar narcosis.
The endpoint calculated here is therefore a reasonable estimate of its
baseline toxicity. The result does not indicate that
1,2,4-trimethylbenzene would meet the criteria for toxic in the PBT
assessment. This endpoint would not affect the classification of the 1,
2, 4-trimethylbenzene since the substance is biodegradable and the log
Kow is < 4.0.
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