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EC number: 284-310-3
CAS number: 84852-02-8
Skin Irritation – minimal irritation for rabbits (OECD 404).Eye Irritation – minimal irritation for rabbits (OECD 405).
The hydroformylation process, which in general terms is a process
involving the preparation of oxygenated organic compounds by the
reaction of carbon monoxide and hydrogen (synthesis gas) with carbon
compounds containing olefinic unsaturation, and is particularly
concerned with the treatment and recycling of by products of the primary
The oxo reaction is performed under hydroformylation conditions in the
presence of a carbonylation catalyst or catalyst precursor such as
dicobaltoctacarbonyl, and results in the formation of a compound e.g. an
aldehyde which has one more carbon atom in its molecular structure than
the feedstock. Subsequent hydrogenation of the primary product leads to
higher alcohols. By virtue of the nature of the feedstock commonly
available to industry, and indeed of the catalyst and reaction
parameters employed, the hydroformylation reaction inevitably yields a
range of products due to the numerous secondary reactions which take
The discard alcohol (1,2-Benzenedicarboxylic acid, di-C1-13 alkyl
esters, manuf. of, by-products from, distn. lights, CAS#84852-02-8) is a
by-product from C6-C8 alcohol formation. Due to compositional
similarity, CAS#98072-31-2, will be used as read-across to fill required
As assessed in dermal irritation studies, CAS # 98072 -31 -2 is
transiently irritating to the skin. In a study utilizing an occluded
patch exposure, the presence of erythema was noted within 4 hours of
patch removal and remained present until at least seven days post
exposure. The severity of the erythema induced by CAS # 98072 -31 -2
exposure ranged from very slight to severe during this time frame.
However, upon removal, signs of irritation subside. CAS # 98072 -31 -2
is also transiently irritating to the eye as assessed in rabbits.
Redness was noted in all animals up to 24h post exposure and decreased
steadily through 14 days post exposure.
No classification for irritation is indicated according to the general
classification and labeling requirements for dangerous substances and
preparations (Directive 67-548-EEC) or the classification, labeling and
packaging (CLP) regulation (EC) No 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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