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EC number: 295-714-4 | CAS number: 92128-22-8
Bioaccumulation: aquatic / sediment
Administrative data
Link to relevant study record(s)
Description of key information
There is no measured data available on aquatic/sediment bioaccumulation for the substance (CAS: 92128-22-8). According to REACH Annex XI, alternative approach should be considered before a new vertebrate test is conducted. The following aspects have been taken into account and in conclusion no aquatic/sediment bioaccumulation test is recommended and the substance is expected to be not bioaccumulative.
- Increased log Kow but low water solubility and, therefore, high potential to surface adsorption and low potential for bioaccumulation. This is supported by high log Koc.
- Experimental study difficult to perform for a UVCB substance.
- Available data on log Kow allow PBT/vPvB assessment and evaluation of B and vB property of the substance. A new experimental study would have no influence on the outcome that the substance is not PBT/vPvB as the substance is not P/vP and not T.
In conclusion, bioaccumulation property may be derived from available log Kow and a new experimental vertebrate study is not expected to be needed.
Key value for chemical safety assessment
- BCF (aquatic species):
- 77.79 L/kg ww
Additional information
Three substances were chosen as representative to allow QSAR estimation of the substance`s bioaccumulation potential: a) and b) are educts and c) is a reaction product.
a) Octadecanoic acid (CAS 57-11-4):
The bioaccumulation factor of octadecanoic acid was estimated to be 10 L/kg using the BCFBAF model included in the EPI-Suite Programm concluding that the substance has alowpotential to bioaccumulate in biota. Within the scope of the Persistency-Bioaccumulation-Toxicity (PBT)-Assessment, the substancedoes not fulfill the B-criterion. Octadecanoic acid falls within the applicability domain described above and, therefore, the predicted value can be considered reliable.
b) 1,3 -Propanediamine, N,N-dimethyl- (CAS 109-55-7):
The bioaccumulation factor of 1,3 -Propanediamine, N,N-dimethyl- was estimated to be 3.162 L/kg using the BCFBAF model included in the EPI-Suite Programm concluding that the substance has a low potential to bioaccumulate in biota. Within the scope of the Persistency-Bioaccumulation-Toxicity (PBT)-Assessment, the substance does not fulfill the B-criterion. 1,3 -Propanediamine, N,N-dimethyl- falls within the applicability domain described above and, therefore, the predicted value can be considered reliable.
c) Fatty acid, tall-oil, compound with N-[3-(dimethylamino)-propyl]-tall-oil amides (CAS 92128-22-8):
The bioaccumulation factor of fatty acid, tall-oil, compound with N-[3-(dimethylamino)-propyl]-tall-oil amides was estimated to be 70.79 L/kg using the BCFBAF model included in the EPI-Suite Programm concluding that the substance has a low potential to bioaccumulate in biota. Within the scope of the Persistency-Bioaccumulation-Toxicity (PBT)-Assessment, the substance does not fulfill the B-criterion. Fatty acid, tall-oil, compound with N-[3-(dimethylamino)-propyl]-tall-oil amides falls within the applicability domain described above and, therefore, the predicted value can be considered reliable.
Concluding, from two educts and a reaction product the highest BCF = 70.79 L/kg is that of the product and this is used for the assessment.
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