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EC number: 206-674-4
CAS number: 366-18-7
Table 1: The effects of single administration of 2,2’-bipyridine
to pregnant rats on litter size and mortality.
Treatment on GD
No. live fetuses
Wet weight [g]
GD: gestation day
Table 2: The effects of single administration of 2,2’-bipyridine
to pregnant rats on embryonal malformations [%].
Fusion of tibia and fibula
Developmental toxicity of 2,2’-bipyridine was assessed by
intraperitoneal application of the test item (at 60 or 75 mg/kg bw) into
pregnant rats on gestation day 11.5, 12.5, 13.5, or 14.5. On gestation
day 21, dams were sacrificed; the fetuses were removed, weighed, and
examined externally. Fetuses were macerated and the cartilaginous
skeleton was examined after staining with methylene blue.
Additionally, limb buds of fetuses removed 10 and 20 h after
administration of the test item on day 12.5 were examined
Intraperitoneal application of 2,2'-bipyridine to pregnant rats
resulted in distinct malformations in the fetuses. Pattern of
malformation was dependent on dose and application time (gestation day).
Abnormalities were mainly observed in the limbs of fetuses. Microscopic
evaluation revealed destruction (autophagocytosis) of mesenchymal stem
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