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Description of key information

One skin irritation study as well as a skin application study are available:

K.S.Williamson (1972), none guideline skin irritation study (rat): severe erythema after 24 h

Swan (1958), none guideline skin irritation study (rat): mild erythema after repeated exposure

Furthermore, observations from acute dermal toxicity studies are available:

K.S.Williamson (1972), Acute dermal toxicity study (rat): severe erythema after 24 h, diminishing over 6 days

S.L.Allen & J.E.Barber (1987), Acute dermal toxicity study (rat): signs of moderate skin irritation

Two studies on eye irritation are available:

K.S.Williamson (1972), non-guideline eye irritation study (rat): inconclusive

Swan (1958), non-guideline study eye irritation study (rat): Not Irritant

The data on skin and eye irriation are too weak to make a conclusion on irritating effects of 2,2'-bipyridine. No data exists to assess respiratory irritation.

Key value for chemical safety assessment

Additional information

Based on the study outline in the various study reports on skin irriation as well as acute dermal toxicity, a conclusion on the irritating effects of the test item to the skin cannot be drawn due to the significantly prolonged exposure time.

Justification for classification or non-classification

Based upon the classification criteria according to regulation (EC) No 1272/2008 of the European Parliment and of the Council of 16 December 2008, classification of the test item for skin irritation is inconclusive.

Based upon the classification criteria according to regulation (EC) No 1272/2008 of the European Parliment and of the Council of 16 December 2008, classification of the the test item for eye irritation is inconclusive.