Registration Dossier
Registration Dossier
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EC number: 223-242-0 | CAS number: 3779-63-3
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
The toxicity to fish (Danio rerio) was assessed according to Directive 92/69/EEC, C.1. The effective concentration expressed in terms of lethal loadings (LL0, 96 h) is estimated to be >= 100 mg/L. The result relates to nominal concentration.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 100 mg/L
Additional information
Should read >100 mg/L
Two acute toxicity studies were performed on HDI Trimer in accordance with the EU Method C.1 and under GLP. A Water Accommodated Fraction procedure was used (100 mg of the test substance was added to 1L of water). Fish (species: Danio rerio) were exposed to the WAF under static conditions. The endpoint is lethal loading rate. In both studies, the 96 -h LL0 was found to be higher than 100 mg/L (nominal concentration).
Disregarded study: For fish (Danio rerio) a LC 50 of 8.9 mg/L (geom. mean.) after 96 h was obtained. The study was conducted according to the German standard method “UBA- Verfahrensvorschlag: Letale Wirkung beim Zebrabärbling (Brachydanio rerio), May 1984”. This study is not regarded as being reliable. Even if the validity criteria are fulfilled according to the validity criteria of 1988 the study design does not meet the criteria of today standard methods. The stirring period of 60 seconds was regarded as too short for a complete hydrolysis of HDI trimer.
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