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EC number: 217-284-9 | CAS number: 1798-50-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- November 17 to november 28, 1997
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: OECD, GLP study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 998
- Report date:
- 1998
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 203 (Fish, Acute Toxicity Test)
- GLP compliance:
- yes
- Remarks:
- Principles of Good Laboratory Practice, annex of paragraph 19a, section 1 of the chemical law.
Test material
- Reference substance name:
- Azacyclonol
- EC Number:
- 204-092-5
- EC Name:
- Azacyclonol
- Cas Number:
- 115-46-8
- IUPAC Name:
- diphenyl(piperidin-4-yl)methanol
- Test material form:
- solid - liquid: suspension
- Details on test material:
- - Name of test material (as cited in study report): Azacyclonol-Base
- Physical state: white powder
- Purity: 98.3 % (w/w)
- Batch No.: 86000298
- Storage conditions: darkness at approximately 5 °C in a refrigerator
- Date of expiry: September 10, 1998
- Solubility in water: not soluble
Constituent 1
Sampling and analysis
- Analytical monitoring:
- yes
- Details on sampling:
- Aqueous solutions of 20ml diluted in methanol.
Test organisms
- Test organisms (species):
- Danio rerio (previous name: Brachydanio rerio)
- Details on test organisms:
- TEST ORGANISM
- Common name: Zebra fish
- Strain: Danio rerio
- Origin: Hoechst Marion Roussel Deutschland GmbH Global Preclinical Development - Drug Safety
- Length at study initiation: 2.6 cm ± 0.08 (variation range: 2.5-2.7)
- Food type: Tetra Min, Tetra Werke, Melle (Germany)
ACCLIMATION
- Acclimation period: 14 days in water for dilution
- Acclimation conditions: light period: 12 hours daily
- Population density: <= 1 g fish/L water
- Food type:Tetra Min, Tetra Werke, Melle (Germany)
- Feeding frequency: twice daily ad libitum
Study design
- Test type:
- static
- Water media type:
- not specified
- Total exposure duration:
- 96 h
Test conditions
- Hardness:
- In a range of 2.3 - 2.5 mmol Ca2+ + Mg2+/ L during the study.
- Test temperature:
- 22 .± 1 °C
- pH:
- Initial pH in study batch: in the range of 8.3-8.5
pH after adding the substance in the 500 mg/L group: 9.6. The pH was adusted with concentrated HCI.
pH after substance addition in the 100 and 220 mg/L groups was below the maximum tolerable value of 9. - Dissolved oxygen:
- >= 80% of the saturation value
Oxygen content in concentration groups: 7.0 - 8.8 mg/L - Nominal and measured concentrations:
- Test concentrations: 0, 100, 220 and 500 mg/L
Nominal concentrations: 0, 100 and 220 mg/L
Measured concentrations: 111 and 243 mg/L - Details on test conditions:
- TEST SYSTEM
- Test vessel: test chambers, which were calibrated to 4 liters
- Aeration: test chambers were not aerated during the course of the study.
- No. of organisms per vessel: 7 fishes
- No. of vessels per concentration (replicates): 4
- No. of vessels per control (replicates): 1
OTHER TEST CONDITIONS
- Adjustment of pH: with HCl
- Photoperiod: from above from 06.00 a.m to 06.00 p.m
- Light intensity: 700 lux
TEST CONCENTRATIONS
Experimental part 1: 7 fish allocated in 2 chambers received 0 and 500 mg/L.
Experimental part 1: 7 fish allocated in 3 chambers received 0, 100 and 220 mg/L.
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 96 h
- Dose descriptor:
- LC0
- Effect conc.:
- ca. 100 mg/L
- Nominal / measured:
- nominal
- Remarks on result:
- other: With the exception of the value observed at study start in the 100 mg/L group (123% of the nominal concentration) all values determined were in a range of± 20 % of the theoretical value.
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- ca. 148 mg/L
- Nominal / measured:
- meas. (not specified)
- Basis for effect:
- mortality (fish)
- Duration:
- 96 h
- Dose descriptor:
- LC100
- Effect conc.:
- ca. 220 mg/L
- Nominal / measured:
- nominal
- Basis for effect:
- mortality (fish)
- Remarks on result:
- other: All values determined were in a range of ± 20 % of the theoretical value.
- Details on results:
- In all tested concentration groups: changes in appearance, behavior, swimming behavior and respiration rate during the entire exposure time.
ln the 500 mg/L groups: recording of symptoms was not possible because of 100 % lethality at the first inspection date.
ln the 2200 mg/L group: symptoms and lethality were observed.
ln the 100 mg/L group: symptoms but no lethality.
Dead fish showed substance deposits on integument, metallic sheen or dark coloured integument. - Reported statistics and error estimates:
- Probit analysis could not be carried out because of the lethality rate. As the factor for the concentration steps was 2.2 (third root of 10), no further concentrations were tested.The geometrie mean of the LC0 and LC100 is given.
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- The LC50 of Azacyclonol-Base after 96 hours was 148 mg/L.
Azacyclonol base induced an increase of the pH > 9 in the test solutions; therefore pH was adjusted by adding concentrated HCl. The ecotoxicity profile of free base could be used as reference.
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