Registration Dossier
Registration Dossier
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EC number: 200-143-0 | CAS number: 52-51-7
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Scientifically acceptable data
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 993
Materials and methods
- Principles of method if other than guideline:
- other: no data
- GLP compliance:
- no
Test material
- Reference substance name:
- Bronopol
- EC Number:
- 200-143-0
- EC Name:
- Bronopol
- Cas Number:
- 52-51-7
- Molecular formula:
- C3H6BrNO4
- IUPAC Name:
- 2-bromo-2-nitropropane-1,3-diol
- Details on test material:
- Bronopol, no further data provided.
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- water
- Details on exposure:
- The test was conducted with a freshly prepared aqueous solution of bronopol and with a solution containing the decomposition products of bronopol. The latter solution was obtained by maintaining an aqueous 1% solution of bronopol (pH 7 - 7.5) at 100 °C for one hour. Both test solutions were tested at the same concentrations, and each test group comprised 2 mice. The mice were observed for mortality.
- Doses:
- 5, 10, 20, 40, 80, 160 and 320 mg/kg bw
- No. of animals per sex per dose:
- 2
Results and discussion
Any other information on results incl. tables
Mortality:
----------
________________________________________________
Dose (mg/kg) / Bronopol / Degraded bronopol
------------------------------------------------
5 / 0/2 / 0/2
------------------------------------------------
10 / 0/2 / 0/2
------------------------------------------------
20 / 1/2 / 0/2
------------------------------------------------
40 / 1/2 / 0/2
------------------------------------------------
80 / 2/2 / 0/2
------------------------------------------------
160 / 2/2 / 0/2
------------------------------------------------
320 / 2/2 / 0/2
________________________________________________
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
