Bronopol

Toxicity to birds

Administrative data

Endpoint:

short-term toxicity to birds: dietary toxicity test

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

other: Guideline study conducted in accordance with GLP.

Data source

Reference

Reference 1

Reference Type:

other: Report

Title:

Unnamed

Year:

1984

Reference 2

Title:

Unnamed

Year:

1984

Reference 3

Reference Type:

study report

Title:

Unnamed

Year:

1984

Report date:

1984

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

EPA OPPTS 850.2200 (Avian Dietary Toxicity Test)

GLP compliance:

yes

Test material

Test material information

Constituent 1

Reference substance name:

Bronopol

EC Number:

200-143-0

EC Name:

Bronopol

Cas Number:

52-51-7

Molecular formula:

C3H6BrNO4

IUPAC Name:

2-bromo-2-nitropropane-1,3-diol

Details on test material:

- Name of test material (as cited in study report): Bronopol
- Lot/batch No.: 104XX
- Analytical purity: 100.2%

Test organisms

Test organisms (species):

Colinus virginianus

Study design

Total exposure duration (if not single dose):

5 d

Results and discussion

Effect levels

Effect levels 1

Duration (if not single dose):

5 d

Dose descriptor:

other: LC0

Effect level:

ca. 500 other: ppm

Conc. / dose based on:

test mat.

Basis for effect:

mortality

Effect levels 2

Duration (if not single dose):

5 d

Dose descriptor:

LC50

Effect level:

4 488 other: ppm

Conc. / dose based on:

test mat.

Basis for effect:

mortality

Effect levels 3

Duration (if not single dose):

5 d

Dose descriptor:

other: LC100

Effect level:

ca. 10 000 other: ppm

Conc. / dose based on:

test mat.

Basis for effect:

mortality

Any other information on results incl. tables

It was observed that birds at 10000 ppm were subdued on day 5. Body weight was within normal limits in all of the groups. No treatment related effect was reported for food consumption. Mortalities were seen in controls (1 animal; bullying) and in groups treated with 1000, 5000 or 10000 ppm (9/10) Bronopol. Of these, several animals showed signs of bullying. LD50 were calculated with and without these animals. LD50 was found to be 4488 ppm (95% confidence limit 2518 to 9827 ppm) in all animals. When animals showing signs of bullying were excluded, the LD50 was found to be 7379 ppm (infinite confidence limits). LD50 for Dieldrin was found to be 59 ppm (95% confidence limits 40-90 ppm).