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Key value for chemical safety assessment

Genetic toxicity in vitro

Description of key information

Tin(II) oxalate was found to be non-genotoxic.

Link to relevant study records
Reference
Endpoint:
in vitro gene mutation study in bacteria
Remarks:
Type of genotoxicity: gene mutation
Type of information:
(Q)SAR
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Justification for type of information:
QSAR prediction: migrated from IUCLID 5.6
Principles of method if other than guideline:
Prediction is done using QSAR Toolbox version 3.1
GLP compliance:
no
Type of assay:
bacterial reverse mutation assay
Species / strain / cell type:
S. typhimurium TA 100
Additional strain / cell type characteristics:
not specified
Metabolic activation:
without
Metabolic activation system:
S9
Species / strain:
S. typhimurium TA 100
Metabolic activation:
without
Genotoxicity:
negative
Cytotoxicity / choice of top concentrations:
not specified
Vehicle controls validity:
not specified
Untreated negative controls validity:
not specified
Positive controls validity:
not specified
Remarks on result:
other: all strains/cell types tested
Remarks:
Migrated from field 'Test system'.

The prediction was based on dataset comprised from the following descriptors: "Gene mutation"
Estimation method: Takes highest mode value from the 5 nearest neighbours
Domain  logical expression:Result: In Domain

(((((("a" or "b" or "c" or "d" or "e" )  and ("f" and ( not "g") )  )  and ("h" and ( not "i") )  )  and "j" )  and "k" )  and ("l" and "m" )  )

Domain logical expression index: "a"

Referential boundary: The target chemical should be classified as Oxocarboxylic acid by Organic functional groups

Domain logical expression index: "b"

Referential boundary: The target chemical should be classified as Overlapping groups AND Oxocarboxylic acid by Organic functional groups (nested)

Domain logical expression index: "c"

Referential boundary: The target chemical should be classified as Anion AND Carbonic acid derivative AND Cation AND Lactone by Organic functional groups, Norbert Haider (checkmol)

Domain logical expression index: "d"

Referential boundary: The target chemical should be classified as Group 14 - Carbon C AND Group 14 - Metals Sn,Pb AND Group 16 - Oxygen O by Chemical elements

Domain logical expression index: "e"

Referential boundary: The target chemical should be classified as Metals by Groups of elements

Domain logical expression index: "f"

Referential boundary: The target chemical should be classified as No alert found by Protein binding by OASIS v1.1

Domain logical expression index: "g"

Referential boundary: The target chemical should be classified as Michael addition OR Michael addition >> Michael addition on conjugated systems with electron withdrawing group OR Michael addition >> Michael addition on conjugated systems with electron withdrawing group >> alpha,beta-carbonyl compounds with polarized double bonds OR Schiff base formation OR Schiff base formation >> Schiff base formation with carbonyl compounds OR Schiff base formation >> Schiff base formation with carbonyl compounds >> Aldehydes by Protein binding by OASIS v1.1

Domain logical expression index: "h"

Referential boundary: The target chemical should be classified as No alert found by DNA binding by OECD

Domain logical expression index: "i"

Referential boundary: The target chemical should be classified as SN1 OR SN1 >> Iminium Ion Formation OR SN1 >> Iminium Ion Formation >> Aliphatic tertiary amines by DNA binding by OECD

Domain logical expression index: "j"

Referential boundary: The target chemical should be classified as Bioavailable by Lipinski Rule Oasis

Domain logical expression index: "k"

Similarity boundary:Target: C1(=O)C(=O)O{-}.[Sn]{2+}.O{-}1
Threshold=10%,
Dice(Atom centered fragments)

Domain logical expression index: "l"

Parametric boundary:The target chemical should have a value of log Kow which is >= -3.62

Domain logical expression index: "m"

Parametric boundary:The target chemical should have a value of log Kow which is <= 0.818

Conclusions:
Interpretation of results (migrated information):negative without metabolic activationBased on the prediction for in-vitro bacterial reverse mutation assay test on Salmonella typhimurium strain TA 100 without S9 metabolic activation it was estimated that tin(II) oxalate does not exhibit positive gene mutation effect.
Executive summary:
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Based on the prediction for in-vitro bacterial reverse mutation assay test on Salmonella typhimurium strain TA 100 without S9 metabolic activation it was estimated that tin(II) oxalate does not exhibit positive gene mutation effect.

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (negative)

Additional information

Additional information from genetic toxicity in vitro:

Genetic toxicity:

No. of studies were reviewed for genetic toxicity with Klimish rating 2 and 4 for the target as well as the read across substance for CAS: 814-94-8.

The summary of the results are presented below

 Sr.No

Endpoint

Interpretation of Results

Species/Strain

Sources

1

In vitro Genetic toxicity

Negative without metabolic activation

S. typhimurium TA 100

Predicted data for CAS: 814-94-8.

2

Chromosome Aberration

Negative without metabolic activation

Chinese hamster Lung (CHL)

Predicted data for CAS: 814-94-8.

3

In vitro Genetic toxicity

Negative with and without metabolic activation

S. typhimurium strains

Data from publication for RA CAS:78-04-6

 

By applying weight of evidence approach to the target substance tin (II) oxalate, it can be concluded that the substance is non-genotoxic with and without metabolic activation. Thus tin (II) oxalate is considered to not classified for genetic toxicity as per the criteria of CLP regulation.

Justification for selection of genetic toxicity endpoint

Based on the prediction for in-vitro bacterial reverse mutation assay test on Salmonella typhimurium strain TA 100 without S9 metabolic activation it was estimated that tin (II) oxalate does not exhibit positive gene mutation effect. Also the chromosome aberration is based on the prediction for in-vitro mammalian chromosome aberration test on Chinese hamster Lung (CHL) without S9 metabolic activation it was estimated that tin (II) oxalate does not exhibit positive chromosomal aberration effect.  

Justification for classification or non-classification

Tin (II) oxalate shows negative activity as is the case for chromosome abberation for the same.