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Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2012
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2012
Report date:
2012

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 436 (Acute Inhalation Toxicity: Acute Toxic Class Method)
GLP compliance:
yes
Test type:
acute toxic class method
Limit test:
no

Test material

Constituent 1
Reference substance name:
tin(II) oxalate
IUPAC Name:
tin(II) oxalate
Constituent 2
Chemical structure
Reference substance name:
Tin(II) oxalate
EC Number:
212-414-0
EC Name:
Tin(II) oxalate
Cas Number:
814-94-8
Molecular formula:
C2H2O4.Sn
IUPAC Name:
tin(II) oxalate
Test material form:
not specified
Details on test material:
- Name of test material (as cited in study report): tin (II) oxalate (obtained from Sigma-Aldrich Chemie GmbH (Steinheim, Germany))
- Purity: 98%

Test animals

Species:
rat
Strain:
other: WIST
Sex:
male/female

Administration / exposure

Route of administration:
inhalation: aerosol
Type of inhalation exposure:
nose only
Vehicle:
air
Mass median aerodynamic diameter (MMAD):
> 1 - < 4 µm
Geometric standard deviation (GSD):
> 1.5 - < 3
Analytical verification of test atmosphere concentrations:
no
Duration of exposure:
4 h
Concentrations:
20.7 mg/L; 8.24 mg/L; 2.97 mg/L
No. of animals per sex per dose:
6
Control animals:
not specified

Results and discussion

Effect levels
Key result
Sex:
male/female
Dose descriptor:
LC50
Effect level:
2 mg/L air
Based on:
test mat.
Exp. duration:
4 h
Mortality:
Concentration Mortality ratio
(mg/L) Males Females
5.0 3/3 3/3
1.0 2/3 1/3
0.5 0/3 0/3

Applicant's summary and conclusion

Interpretation of results:
Category 4 based on GHS criteria
Conclusions:
The acute median lethal concentration of the test article, Zinn (II) Oxalat, was found
to be 2 mg/L.
The test material was classified as Category 4 in respect of its acute inhalation toxicity
according to the Globally Harmonized System of Classification and Labelling of
Chemicals (GHS).

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