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Toxicological information

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Description of key information

Key value for chemical safety assessment

Acute toxicity: via oral route

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Reference
Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
other: no glp, no guideline followed, primary literature source not available
Qualifier:
no guideline available
Principles of method if other than guideline:
no data
GLP compliance:
no
Species:
rat
Strain:
not specified
Sex:
not specified
Route of administration:
oral: unspecified
Vehicle:
not specified
Doses:
no data
No. of animals per sex per dose:
no data
Control animals:
not specified
Sex:
not specified
Dose descriptor:
LD50
Effect level:
3 620 mg/kg bw
Based on:
not specified

no data

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
LD50(rat, oral) 3620 mg/kg bw
Endpoint conclusion
Endpoint conclusion:
adverse effect observed
Dose descriptor:
LD50
Value:
3 620 mg/kg bw

Acute toxicity: via inhalation route

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Reference
Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2012
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 436 (Acute Inhalation Toxicity: Acute Toxic Class Method)
GLP compliance:
yes
Test type:
acute toxic class method
Limit test:
no
Species:
rat
Strain:
other: WIST
Sex:
male/female
Route of administration:
inhalation: aerosol
Type of inhalation exposure:
nose only
Vehicle:
air
Mass median aerodynamic diameter (MMAD):
> 1 - < 4 µm
Geometric standard deviation (GSD):
> 1.5 - < 3
Analytical verification of test atmosphere concentrations:
no
Duration of exposure:
4 h
Concentrations:
20.7 mg/L; 8.24 mg/L; 2.97 mg/L
No. of animals per sex per dose:
6
Control animals:
not specified
Key result
Sex:
male/female
Dose descriptor:
LC50
Effect level:
2 mg/L air
Based on:
test mat.
Exp. duration:
4 h
Mortality:
Concentration Mortality ratio
(mg/L) Males Females
5.0 3/3 3/3
1.0 2/3 1/3
0.5 0/3 0/3
Interpretation of results:
Category 4 based on GHS criteria
Conclusions:
The acute median lethal concentration of the test article, Zinn (II) Oxalat, was found
to be 2 mg/L.
The test material was classified as Category 4 in respect of its acute inhalation toxicity
according to the Globally Harmonized System of Classification and Labelling of
Chemicals (GHS).
Endpoint conclusion
Endpoint conclusion:
adverse effect observed
Dose descriptor:
LC50
Value:
2 000 mg/m³ air

Acute toxicity: via dermal route

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Reference
Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
other: no glp, no guideline, no year, no primary source available
Qualifier:
no guideline available
Principles of method if other than guideline:
no data
GLP compliance:
no
Test type:
other: no data
Limit test:
no
Species:
rabbit
Strain:
not specified
Sex:
not specified
Type of coverage:
not specified
Vehicle:
not specified
Duration of exposure:
no data
Doses:
no data
No. of animals per sex per dose:
no data
Control animals:
not specified
Key result
Sex:
not specified
Dose descriptor:
other: LD
Effect level:
> 2 000 mg/kg bw
Based on:
not specified

no data

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
LD > 2000 mg/kg bw
Endpoint conclusion
Endpoint conclusion:
adverse effect observed
Dose descriptor:
LD50
Value:
2 001 mg/kg bw

Additional information

Justification for classification or non-classification