Registration Dossier
Registration Dossier
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EC number: 212-414-0 | CAS number: 814-94-8
Toxicological information
Toxicological Summary
Currently viewing:
Administrative data
Workers - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 0.15 mg/m³
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- By inhalation
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 30
- Modified dose descriptor starting point:
- NOAEC
- Value:
- 9.19 mg/m³
- Explanation for the modification of the dose descriptor starting point:
- n.a., no route extrapolation
- AF for dose response relationship:
- 1
- Justification:
- default factor
- AF for differences in duration of exposure:
- 6
- Justification:
- default factor for subacute to chronic
- AF for interspecies differences (allometric scaling):
- 1
- Justification:
- not required for inhalation
- AF for other interspecies differences:
- 1
- Justification:
- not required for inhalation
- AF for intraspecies differences:
- 5
- Justification:
- default value worker
- AF for the quality of the whole database:
- 1
- Justification:
- default factor
- AF for remaining uncertainties:
- 1
- Justification:
- default factor
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 0.01 mg/m³
- Most sensitive endpoint:
- irritation (respiratory tract)
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 90
- Dose descriptor:
- LOAEC
- Value:
- 2.44 mg/m³
- AF for dose response relationship:
- 3
- Justification:
- default factor LOAEL
- AF for differences in duration of exposure:
- 6
- Justification:
- default factor for subacute to chronic
- AF for interspecies differences (allometric scaling):
- 1
- Justification:
- not required for inhalation
- AF for other interspecies differences:
- 1
- Justification:
- not required for inhalation
- AF for intraspecies differences:
- 5
- Justification:
- default factor worker
- AF for the quality of the whole database:
- 1
- Justification:
- default factor
- AF for remaining uncertainties:
- 1
- Justification:
- default factor
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Workers - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
Workers - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- low hazard (no threshold derived)
Additional information - workers
General Population - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DMEL (Derived Minimum Effect Level)
- Value:
- 0.01 mg/m³
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- By inhalation
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 450
- Modified dose descriptor starting point:
- NOAEC
- Value:
- 9.19 mg/m³
- Explanation for the modification of the dose descriptor starting point:
- n.a. no route extrapolationb
- AF for dose response relationship:
- 1
- Justification:
- default factor
- AF for differences in duration of exposure:
- 6
- Justification:
- default factor subacute to chronic
- AF for interspecies differences (allometric scaling):
- 1
- Justification:
- not required for inhalation
- AF for other interspecies differences:
- 1
- Justification:
- not required for inhalation
- AF for intraspecies differences:
- 10
- Justification:
- default factor public
- AF for the quality of the whole database:
- 1
- Justification:
- default factor
- AF for remaining uncertainties:
- 1
- Justification:
- default factor
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- DMEL (Derived Minimum Effect Level)
- Value:
- 0.005 ng/m³
- Most sensitive endpoint:
- irritation (respiratory tract)
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 180
- Dose descriptor:
- LOAEC
- AF for dose response relationship:
- 3
- Justification:
- default LOAEC
- AF for differences in duration of exposure:
- 6
- Justification:
- subacute to chronic
- AF for interspecies differences (allometric scaling):
- 1
- Justification:
- hot required for local
- AF for other interspecies differences:
- 1
- Justification:
- hot required for local
- AF for intraspecies differences:
- 10
- Justification:
- public
- AF for the quality of the whole database:
- 1
- Justification:
- default factor
- AF for remaining uncertainties:
- 1
- Justification:
- default factor
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
General Population - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
General Population - Hazard via oral route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DMEL (Derived Minimum Effect Level)
- Value:
- 0.45 mg/kg bw/day
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- Oral
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 200
- Modified dose descriptor starting point:
- NOAEL
- Value:
- 51.9 mg/kg bw/day
- Explanation for the modification of the dose descriptor starting point:
- not relevant, oraö tp oral
- AF for dose response relationship:
- 1
- Justification:
- Default factor
- AF for differences in duration of exposure:
- 2
- Justification:
- sub-chronic to chronic
- AF for interspecies differences (allometric scaling):
- 4
- Justification:
- allometic scaling factor
- AF for other interspecies differences:
- 2.5
- Justification:
- default factor
- AF for intraspecies differences:
- 10
- Justification:
- public
- AF for the quality of the whole database:
- 1
- Justification:
- default factor
- AF for remaining uncertainties:
- 1
- Justification:
- default factor
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
General Population - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- no hazard identified
Additional information - General Population
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
