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EC number: 242-582-0
CAS number: 18794-84-8
Table 1. Occurrence of delayed ossification in
foetuses of rats treated orally with β-myrcene on Days 6-15 of
β-Myrcene (mg/kg bw)
Foetuses examined (no.)
Percentage of foetuses with signs of delayed ossificationαin:
αSigns of delayed ossification: not ossified
(whole bone is not stained), poorly ossified (whole bone is poorly
stained), and irregular spongy bones.
* P < 0.05; chi-square test
A study was conducted to evaluate the embryo-foetotoxic potential
of β-myrcene in the Wistar rats similarly to OECD Guideline 414.
β -Myrcene (250, 500 and 1200 mg/kg bw/day) in corn oil was given
orally to Wistar rats from Day 6 to 15 of pregnancy. Two control groups,
one received vehicle only and another without treatment, were also
studied simultaneously. All rats were weighed on Day 0, 6, 16 and 20 of
pregnancy. Caesarean sections were performed on Day 20 of pregnancy, and
the number of resorptions and implantation sites were recorded. Foetuses
were weighed and examined for external, visceral and skeletal
A significant effect (decrease) on maternal body weight gain (~ 82%%)
was seen during gestation days 6 to 11, at 1200 mg/kg. There was also an
increased incidence of delayed foetal ossification in the 1200 mg/kg
dose group. At lower dose levels no maternal or foetal effects were
observed that were considered to be related to treatment. The
possibility that the delay in skeletal ossification seen in foetuses at
1200 mg/kg may have been caused indirectly by the significant maternal
toxicity cannot be precluded.
In conclusion, the no-observed-adverse-effect level (NOAEL) for
maternal toxicity and for embryo-foetotoxicity of β -myrcene
administered orally (gavage) was reported to be 500 mg/kg bw/day in
Wistar rats. This effect may however have arisen due to the significant
maternal toxicity seen at 1200 mg/kg, rather than due to a direct effect
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