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EC number: 242-582-0
CAS number: 18794-84-8
Three healthy New Zealand White rabbits (2 males - 1 female), free from
ocular irritation and corneal abnormalities, were dosed with
trans-ß-farnesene, Lot# KJF-134-53-03,
CAS# 18794-84-8. The test article (0.1 ml) was placed into the
conjunctival sac of one eye of each
rabbit. The contralateral eye served as a control. The eyes were
examined and scored by the Draize
technique at 1, 24, 48 and 72 hours. Sodium fluorescein dye procedures
were used at the 24-hour
observation interval. Body weights were recorded pretest.
There was no corneal opacity or iritis noted in any animal at any
observation period. Mild conjunctival irritation (redness, swelling and
some discharge) noted in the eyes of 3/3 animals 1 hr after treatment
had cleared within 72 hours. There were no abnormal physical signs noted
during the observation period.
Following instillation into the rabbit eye, trans-beta farnesene
provoked only minimal occular irritation. Reactions did not meet the
criteria for classification as an eye irritant per EU CLP criteria.
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