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EC number: 242-582-0
CAS number: 18794-84-8
Since the test article was not expected to
produce severe irritation or corrosion, three healthy New Zealand White
rabbits (2 males - 1 female) were dosed dermally with trans-ß-farnesene,
Lot# KJF-134-53-03, CAS# 18794-84-8. The test article (0.5 ml) was
applied dermally to one intact site/rabbit and kept in contact with the
skin for 4 hours at which time the wrappings were removed.
Dermal reactions were scored at 60 minutes
after removal of wrappings. Reactions were scored again at 24, 48 and 72
hours following patch removal. The skin was also evaluated for
ulceration and necrosis or any evidence of tissue destruction at these
time periods. Body weights were recorded pretest and at termination.
Erythema was very slight to well defined at
60 minutes and well defined at 24, 48 and 72 hours following the 4 hour
exposure. Edema was very slight to moderate at 60 minutes and slight at
24, 48 and 72 hours following the 4 hour exposure. There were no
abnormal physical signs noted during the observation period. Two animals
lost weight. All other body weight changes were normal.
Dermal application of trans-ß-farnesene
caused only mild skin reaction in rabbits following a 4hr semi-occlusive
exposure. Skin reactions did not meet the criteria for classification as
as a dermal irritant in accordance with EU CLP regulations.
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