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EC number: 242-582-0
CAS number: 18794-84-8
The acute dermal toxicity of farnesene was investigated in rabbits. The
test material was applied to the shaved dorsal skin of 5 male and 5
female rabbits at 5000 mg/kg of body weight, under an occlsive dressing.
The test article was kept in contact with the skin for 24 hours. Dermal
responses were recorded at 24 hours postdose and on days 7 and 14.
Animals were observed for toxicity and pharmacological effects at 1, 2
and 4 hours postdose and once daily for 14 days. All animals were
observed twice a day for mortality.
Body weights were recorded pretest, weekly and at termination. All
animals were examined for gross pathology. Abnormal tissues were
preserved in 10% neutral buffered formalin for possible future
There were no deaths during the study and all animals survived the 5000
mg/kg dermal application in good health. Dermal responses were absent to
very slight at 24 hours, very slight to well defined on day 7 and very
slight on day 14. Additionally, pale areas, flaking skin and areas of
poor hair regrowth were noted during the study. Slight body weight loss
was noted on day 7 in 8/10 animals, but all returned to normal by day
14. Treated skin abnormalities were the only abnormality noted at
The dermal LD50 of trans-ß-farnesene, in the rabbit is greater than 5000
mg/kg of body weight.
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