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EC number: 242-582-0
CAS number: 18794-84-8
Five healthy male and five healthy female Sprague Dawley rats were
exposed to an aerosol atmosphere of farnesene at a concentration of 2.06
mg/L for 4 hours. Chamber temperature, relative
humidity of air entering the chamber, chamber air flow and negative
pressure were monitored and recorded. All rats were
monitored during the exposure period, one hour after exposure, and once
daily thereafter for 14 days for toxicity and pharmacological effects. The
rats were observed twice daily for mortality. Body
weights were recorded prior to exposure, weekly, and at termination. All
animals were examined for gross pathology. Abnormal
tissues were preserved in 10% neutral buffered formalin for possible
future histologic examination.
The target concentration was estimated prior to exposure. Actual
concentrations were determined gravimetrically during exposure. Particle
size analyses revealed an average mass median aerodynamic diameter of
0.86 micrometer with an average geometric standard deviation of 3.16
All animals survived the four hour 2.06 mg/L exposure. Instances
of piloerection, wetness of the anogenital area, closed eyes, ocular
lacrimation/crust formation and coating of the fur with test article
were noted during the exposure. Chromorhinorrhea,
piloerection, wetness of the anogenital area, soiling of the anogtenital
area, few faeces, coating of the fur with test article and localized
alopecia were noted during the remainder of the study. Body
weight changes were normal in 6/10 animals. Instances
of weight loss were noted in four females. Necropsy
results were normal in 9/10 animals. Localized
alopecia was noted in one female. The rat 4 hour inhalation LC50 is >
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