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EC number: 242-582-0
CAS number: 18794-84-8
one healthy female Wistar albino rat was dosed orally with
KJF-134-53-03, CAS# 18794-84-8) at 5000 mg/kg. Since the animal
survived, two additional
animals were dosed at 5000 mg/kg. The rats were observed at 15 minutes,
1, 2 and 4 hours postdose
and once daily for 14 days for toxicity and pharmacological effects. All
animals were observed twice
daily for mortality. Body weights were recorded immediately pretest,
weekly and at termination. All animals
were examined for gross pathology. The potential for toxicity was based
on the mortality response
females survived the 5000 mg/kg oral dose. Instances
of soiling, wetness and yellow staining of the anogenital area,
piloerection, localized alopecia and
chromorhinorrhea were noted during the observation period.
changes were normal in 2/3 animals. One animal lost weight during the
second week of the observation
no macroscopic observations during terminal necropsy.
trans-ß-farnesene following oral administration to the rat was greater
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