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EC number: 242-582-0
CAS number: 18794-84-8
No chronic aquatic toxicity data are available for farnesene. Based on a read-across study with a structural analogue - farnesane, the NOEC for chronic toxicity of farnesene to daphnia is predicted to be greater than the limit of water solubility (11 μg/L). See read across justification section 13
chronic aquatic toxicity data are available for farnesene. Based on a
read-across study with a structural analogue - farnesane, the NOEC for
chronic toxicity to daphnia is predicted to be greater than the limit of
water of water solubility.
a read across chronic daphnia study, there were no effects on survival
or dry weight at the highest dose tested (77
exposed at a concentration of 77 μg a.i./L had statistically significant
reductions in length and reproduction in comparison to the pooled
NOEC, based on growth and reproduction, was therefore 54 μg a.i./L. The
LOEC was 77 μg a.i./L and the MATC w
calculated to be 64 μg a.i./L. The 21-day EC50 values for adult
immobility and reproduction
were both >77 μg a.i./L, the highest concentration tested.
this study solvent was used to enhance the water solubility of farnesane
which is known to be highly insoluble; this approach is often used in
ecotoxicity studies with substances that are not readily soluble in
water. The results provide an indication of the possible toxicity of the
substance if it were capable of dissolution. However, these are not
naturally occurring conditions and hence water solubility and exposure
of organisms are overestimated. The measured water solubility of
farnesane is 0.25 μg/L
and, based on results of this study, no toxicity would be expected at
this concentration under normal environmental conditions.
Based on read across to the analogue farnesane, it is predicted that
farnesene would not cause toxicity to daphnia following chronic exposure
at the limit of water solubility (11 μg/L).
for the use of read-across data can be found in section 13 of the
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