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EC number: 242-582-0
CAS number: 18794-84-8
The biodegradability of Farnesene in water has been assessed in three
screening studies. All three studies were designed to comply with the
standards set forth in OECD Guidelines for the testing of Chemicals,
OECD Guideline 301 B (Ready Biodegradability: CO2 Evolution Test).
In the key study (BMG 2011a), farnesene did not meet the criteria to be
considered as readily biodegradable, It did however achieve 60%
biodegradation within 28 days, showing a clear potential to degrade in
In two supporting OECD 301B studies, the level of biodegradability seen
at 28 days was 39% and 54%, supporting the conclusion that farnesene has
the potential to degrade in the environment.
The biodegradability of farnesene in water has been investigated in
three screening studies (OECD 301B). In the key study (BMG 2011a)
farnesene (FnM3132) was exposed to microorganisms derived from the
activated sludge of a municipal sewage treatment plant under aerobic
static exposure conditions. The biodegradability - based on CO2
evolution - of FnM3132 was calculated to be 61% of the theoretical value
(ThCO2) after an incubation time of 28 days, achieving 53% at the end of
the 10-d window. Significant biodegradation of the test substance was
observed after a lag phase of about 3 days.The positive control, sodium
benzoate, reached 91% biodegradation after 14 days, thus confirming
suitability of inoculum and test conditions.
Farnesene did not reach the pass level of 60% for ready biodegradability
in the CO2 Evolution Test within the 10-d window and, therefore, cannot
be termed as readily biodegradable. However, the test substance achieved
more than 60% degradation after 28 days, showing a clear potential for
degradation in the environment.
Farnesene also showed clear potential for degradation in the environment
in two supporting studies (Edward 2001, BMG 2011b). In these two
studies, farnesene did not meet the criteria (60% biodegradation) to be
described as readily biodegradable, achieving 39 and 54% respectively by
28 days. Nevertheless the level of degradation was sufficient to show
potential for degradation in an aqueous environment.
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