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EC number: 939-967-7 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- 5 November 1990 - 8 November 1990
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study performed in accordance with generally accepted scientific principles, possibly with incomplete reporting or methodological deficiencies, which do not affect the quality of the relevant results.
Data source
Referenceopen allclose all
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 990
- Report date:
- 1990
- Reference Type:
- publication
- Title:
- Acute Toxicological Evaluation of Erbium Oxide
- Author:
- Lambert, C.E., Barnum, E.C. and Shapiro, R.
- Year:
- 1 993
- Bibliographic source:
- Int. J. Toxicol., 12(6): 619
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- other: FHSA 16 CFR 1500.41
- Deviations:
- no
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Dierbium trioxide
- EC Number:
- 235-045-7
- EC Name:
- Dierbium trioxide
- Cas Number:
- 12061-16-4
- Molecular formula:
- Er2O3
- IUPAC Name:
- Dierbium trioxide
- Test material form:
- solid: particulate/powder
- Details on test material:
- Appearance: pink powdered solid
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Acclimation period: 12 days.
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 19 - 23 °C
IN-LIFE DATES: From: 5 November 1990 To: 8 November 1990
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- other: abraded and shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- 0.5 g of the test material was placed on each of the test sites (i.e. abraded and intact skin).
- Duration of treatment / exposure:
- 24 hours
- Observation period:
- 72 hours. Evaluation occurred 24 and 72 hours after exposure.
- Number of animals:
- 6
- Details on study design:
- TEST SITE
- Area of exposure: 2.5 cm² (two per rabbit, one intact and one abraded).
REMOVAL OF TEST SUBSTANCE
- Washing (if done): the test sites were gently wiped clean of any residual test material.
- Time after start of exposure: after 24 hours of exposure.
SCORING SYSTEM:
Erythema and eschar formation:
0: No erythema:
1: Very slight erythema (barely perceptible)
2: Well-defined erythema
3: Moderate to severe erythema
4: Severe erythema (beet redness) or eschar formation (injuries in depth) preventing erythema reading
Oedema formation:
0: No oedema
1: Very slight oedema (barely perceptible)
2: Slight oedema (edges of area well-defined by definite raising)
3: Moderate oedema (edges raised approximately 1 millimetre)
4: Severe oedema (raised more than 1 millimetre and extending beyond the area of exposure)
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- primary dermal irritation index (PDII)
- Basis:
- mean
- Remarks:
- of 6 animals
- Time point:
- other: mean at 24 and 72 hours
- Score:
- 0
- Max. score:
- 0
- Reversibility:
- other: not applicable
- Irritation parameter:
- erythema score
- Basis:
- mean
- Remarks:
- of 6 animals
- Time point:
- other: mean at 24 and 72 hours
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: not applicable
- Remarks on result:
- other: Intact skin
- Irritation parameter:
- erythema score
- Basis:
- mean
- Remarks:
- of 6 animals
- Time point:
- other: mean at 24 and 72 hours
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: not applicable
- Remarks on result:
- other: Abraded skin
- Irritation parameter:
- edema score
- Basis:
- mean
- Remarks:
- of 6 animals
- Time point:
- other: mean at 24 and 72 hours
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: not applicable
- Remarks on result:
- other: Intact skin
- Irritation parameter:
- edema score
- Basis:
- mean
- Remarks:
- of 6 animals
- Time point:
- other: mean of 24 and 72 hours
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: not applicable
- Remarks on result:
- other: Abraded skin
- Irritant / corrosive response data:
- All sites were clear of irritation during the test period.
- Other effects:
- All animals appeared active and healthy.
Any other information on results incl. tables
Table 1 Primary Dermal Irritation (PDI) Scores - Individual Results
Rabbit |
24 hours |
72 hours |
||
Abraded |
Intact |
Abraded |
Intact |
|
7740 7741 7742 7743 7744 7745 |
0/0 0/0 0/0 0/0 0/0 0/0 |
0/0 0/0 0/0 0/0 0/0 0/0 |
0/0 0/0 0/0 0/0 0/0 0/0 |
0/0 0/0 0/0 0/0 0/0 0/0 |
Total |
0/0 |
0/0 |
0/0 |
0/0 |
Mean |
0/0 |
0/0 |
0/0 |
0/0 |
Key: erythema and eschar / oedema
Applicant's summary and conclusion
- Interpretation of results:
- other: Not classified according to EU criteria.
- Conclusions:
- Under the conditions of this study, the test material is not irritating to skin and requires no classification in accordance with the EU criteria.
- Executive summary:
The primary skin irritation potential of the test material was investigated in a study which was broadly conducted in accordance with the FHSA guideline 16 CFR 1500.41.
During the study 0.5 g of the test material was applied to both an intact and abraded site on each of six New Zealand White rabbits. The sites were occluded for 24 hours. The patches were then removed and the test sites wiped to prevent further exposure. Evaluation occurred 24 and 72 hours after exposure.
All sites were clear of irritation during the test period and the Primary Dermal Irritation Index was 0.0.
Under the conditions of this study, the test material is not irritating to skin and requires no classification in accordance with the EU criteria.
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