Registration Dossier

Diss Factsheets

Administrative data

Workers - Hazard via inhalation route

Systemic effects

Long term exposure
Hazard assessment conclusion:
no hazard identified
Acute/short term exposure
Hazard assessment conclusion:
no hazard identified
DNEL related information

Local effects

Long term exposure
Hazard assessment conclusion:
no hazard identified
Acute/short term exposure
Hazard assessment conclusion:
no hazard identified
DNEL related information

Workers - Hazard via dermal route

Systemic effects

Long term exposure
Hazard assessment conclusion:
no hazard identified
Acute/short term exposure
Hazard assessment conclusion:
no hazard identified
DNEL related information

Local effects

Long term exposure
Hazard assessment conclusion:
no hazard identified
Acute/short term exposure
Hazard assessment conclusion:
no hazard identified

Workers - Hazard for the eyes

Local effects

Hazard assessment conclusion:
no hazard identified

Additional information - workers

1. Information on zirconium dioxide (CAS# 1314-23-4)


The available toxicological data on zirconium dioxide indicate that there is no need to derive DNEL values, as no hazards could be identified in any of the available tests. Not all available tests have however been included in this dossier because in this dossier only Annex VIII endpoints need to be covered.


Nevertheless, currently there are some regulatory values available for occupational exposure via inhalation, such as the following:


- TWA (time weighted average): 5 mg/m3


- STEL (short-term exposure limit): 10 mg/m3


 


2. Information on erbium oxide (CAS# 12061-16-4)


The available toxicological data on erbium oxide indicate that there is no need to derive DNEL values, as no hazards could be identified in any of the available tests. Not all available tests have however been included in this dossier because in this dossier only Annex VIII endpoints need to be covered, and according to the read across strategy only Annex VII data for erbium oxide have been included in the dossier.


No regulatory exposure limits are available for occupational exposure.


 


3. Conclusion on erbium zirconium oxide


Based on the toxicological data available on zirconium dioxide and erbium oxide, it can be concluded that there is no need to derive DNEL values, as no hazards could be identified in any of the available tests.

General Population - Hazard via inhalation route

Systemic effects

Long term exposure
Hazard assessment conclusion:
no hazard identified
Acute/short term exposure
Hazard assessment conclusion:
no hazard identified
DNEL related information

Local effects

Long term exposure
Hazard assessment conclusion:
no hazard identified
Acute/short term exposure
Hazard assessment conclusion:
no hazard identified
DNEL related information

General Population - Hazard via dermal route

Systemic effects

Long term exposure
Hazard assessment conclusion:
no hazard identified
Acute/short term exposure
Hazard assessment conclusion:
no hazard identified
DNEL related information

Local effects

Long term exposure
Hazard assessment conclusion:
no hazard identified
Acute/short term exposure
Hazard assessment conclusion:
no hazard identified

General Population - Hazard via oral route

Systemic effects

Long term exposure
Hazard assessment conclusion:
no hazard identified
Acute/short term exposure
Hazard assessment conclusion:
no hazard identified
DNEL related information

General Population - Hazard for the eyes

Local effects

Hazard assessment conclusion:
no hazard identified

Additional information - General Population

1. Information on zirconium dioxide (CAS# 1314-23-4)


The available toxicological data on zirconium dioxide indicate that there is no need to derive DNEL values, as no hazards could be identified in any of the available tests.


2. Information on erbium oxide (CAS# 12061-16-4)


The available toxicological data on erbium oxide indicate that there is no need to derive DNEL values, as no hazards could be identified in any of the available tests.


3. Conclusion on erbium zirconium oxide


Based on the toxicological data available on zirconium dioxide and erbium oxide, it can be concluded that there is no need to derive DNEL values, as no hazards could be identified in any of the available tests.

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