2,4-dinitrophenol

Other distribution data

Administrative data

Endpoint:

other distribution data

Type of information:

experimental study

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Data have been obtained from secondary source.

Data source

Reference

Reference 1

Reference Type:

secondary source

Title:

Toxicological Profile for dinitrophenol

Author:

M. Olivia Harris, M.A; James J. Corcoran, Ph.D. (peer rewied by Dr. Martin Alexander; Dr.Leon Koller; Dr.Norman Trieff)

Year:

1995

Bibliographic source:

U.S Department of Health and human Services, Public Health Service Agency for Toxic Substances and Disease Registry

Reference 2

Reference Type:

review article or handbook

Title:

Studies on photochemical reaction of air pollutants: X. Identification of nitrophenols in suspended particulates.

Author:

Nojima K, Kawaguchi A, Ohya T, et al.

Year:

1983

Bibliographic source:

Chem Pharm Bull 31: 1047-1051, 1983

Materials and methods

Principles of method if other than guideline:

Gas chromatographic (GC) and high-performance liquid chromatographic (HPLC) columns are often used as the final step towards resolution with a a variety of detectors to quantify dinitrophenols; The method consisted in the detection of both 2,4- and 2,6-DNP in particulate matter in air in Yokohama, Japan for 5 days.

GLP compliance:

not specified

Test material

Test material information

Constituent 1

Reference substance name:

2,4-dinitrophenol

EC Number:

200-087-7

EC Name:

2,4-dinitrophenol

Cas Number:

51-28-5

Molecular formula:

C6H4N2O5

IUPAC Name:

2,4-dinitrophenol

Results and discussion

Any other information on results incl. tables

The reported concentration ranges of 2,4 -dinitrophenol in particulate matter in air in Yokohama, Japan, during 5 days were 2.4-12 μg/g particulates, that are indirect indications of the presence of these compounds in the air.

The observation that dinitrophenols are found at least partly in the particulate-sorbed state in the air indicates that their bioavailability from air is < 100%.

Applicant's summary and conclusion

Conclusions:

The reported concentration ranges of 2,4 -dinitrophenol in particulate matter in air in Yokohama, Japan, during 5 days were 2.4-12 μg/g particulates, that are indirect indications of the presence of these compounds in the air.
The observation that dinitrophenols are found at least partly in the particulate-sorbed state in the air indicates that their bioavailability from air is < 100%.

Executive summary:

Data have been obtained from secondary source that mentions Nojima K, Kawaguchi A, Ohya T, et al. 1983. Studies on photochemical reaction of air pollutants: X. Identification of nitrophenols in suspended particulates. Chem Pharm Bull 31: 1047-1051.

The method consisted in the detection of both 2,4- and 2,6-DNP was done by GC in particulate matter in air in Yokohama, Japan for 5 days.

Because underivatized nitrophenols are irreversibly sorbed on active sites of GC column materials, it may be necessary to derivatize the compounds to increase their volatility to enhance elution from the GC column.

The reported concentration ranges of 2,4 -dinitrophenol in particulate matter in air in Yokohama during the 5 days were 2.4-12 μg/g particulates, that are indirect indications of the presence of these compounds in the air.

The observation that dinitrophenols are found at least partly in the particulate-sorbed state in the air indicates that their bioavailability from air is < 100%.