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EC number: 278-047-3
CAS number: 74993-03-6
mutagenic potential of the test article (CASRN 74993-03-6, Appearance,
purity and batch not reported) was evaluated in the Bacterial Reverse
Mutation Assay with S. thyphimurium strains TA 98, TA 100, TA 1535, TA
1537, and TA 1538 in the presence and absence of a metabolic activation
system (S9 mix).
The study was not GLP compliant. The
test method was based on Huntingdon Research Centre Protocol MCB/101.
The test article (solvent not listed) was dosed at 0.1, 1, 10, and 100
experiments were performed in the presence and absence of metabolic
specific positive controls and vehicle controls were tested in parallel. The
test article produced a 1 0 -270 -fold, dose related increase of control
values in the number of revertant colonies in tester strains TA 1535, TA
98, and TA 100 in the presence and absence of metabolic activation. There
was no increase in revertant colonies in treated TA 1537 and TA 1538
strains in the presence and absence of metabolic activation.
Based on the results of the study, the test article was mutagenic in the
Bacterial Reverse Mutation Assay in the presence and absence of
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