Registration Dossier
Registration Dossier
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EC number: 410-260-0 | CAS number: 83857-96-9 2-BUTYL-4-CHLORO-5-FORMYLIMIDAZOLE; BCFI
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- other: Body responsible for the test
- Title:
- Unnamed
- Year:
- 1 993
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Directive84/449/CEE - B1
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- 2-butyl-4-chloro-5-formylimidazole
- EC Number:
- 410-260-0
- EC Name:
- 2-butyl-4-chloro-5-formylimidazole
- Cas Number:
- 83857-96-9
- Molecular formula:
- C8 H11 Cl N2 O
- IUPAC Name:
- 2-butyl-4-chloro-1H-imidazole-5-carbaldehyde
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- CMC (carboxymethyl cellulose)
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Mortality:
- Male: 2000mglkg bw; Number of animals: 5; Number of deaths: 0
Male: 5000 mglkg bw; Number of animals: 5; Numberof deaths: 3
Female: 2000 mglkg bw; Number of animals: 5; Number of deaths: 0 - Clinical signs:
- other: Signs of toxicity related to dose levels: à 2000 mg/kg : hypocinésie, sudation, trouble respiratoire, ataxie, piloérection et ralentissement de I'évolution pondérale. Ces signes s'observent a un deqré varié jusqu'au 5ème jour. - à 5000 mg/kg : on observe
- Gross pathology:
- Effects on organs:
Aucune anomalie macroscopique n'a été mise en évidence.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
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