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Diss Factsheets

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)

Data source

Reference
Reference Type:
other: Body responsible for the test
Title:
Unnamed
Year:
1993

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: Directive84/449/CEE - B1
GLP compliance:
yes
Test type:
standard acute method
Limit test:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
2-butyl-4-chloro-5-formylimidazole
EC Number:
410-260-0
EC Name:
2-butyl-4-chloro-5-formylimidazole
Cas Number:
83857-96-9
Molecular formula:
C8 H11 Cl N2 O
IUPAC Name:
2-butyl-4-chloro-1H-imidazole-5-carbaldehyde

Test animals

Species:
rat
Strain:
Sprague-Dawley
Sex:
male/female

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
CMC (carboxymethyl cellulose)

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 2 000 mg/kg bw
Mortality:
Male: 2000mglkg bw; Number of animals: 5; Number of deaths: 0
Male: 5000 mglkg bw; Number of animals: 5; Numberof deaths: 3
Female: 2000 mglkg bw; Number of animals: 5; Number of deaths: 0
Clinical signs:
other: Signs of toxicity related to dose levels: à 2000 mg/kg : hypocinésie, sudation, trouble respiratoire, ataxie, piloérection et ralentissement de I'évolution pondérale. Ces signes s'observent a un deqré varié jusqu'au 5ème jour. - à 5000 mg/kg : on observe
Gross pathology:
Effects on organs:
Aucune anomalie macroscopique n'a été mise en évidence.

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: EU