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EC number: 917-473-2
CAS number: -
The physical properties of the test substance particularly the high
water solubility (HLS, 1996) and low partition coefficient (HLS, 1996)
would suggest that if the substance was bioavailable it would be
unlikely to pass into the central nervous system. Acute toxicology
particularly the acute oral study (HLS), revealed systemic effects of
the test substance in the form of clinical signs. Clear evidence of oral
absorption was seen in both the acute and repeated dose studies. There
was some limited evidence of absorption via the dermal route. In a 28
-day oral (gavage) study (HLS, 1998), rats were dosed with 15, 50 or 150
mg/kg/day. The 28 Day Oral Toxicity Study revealed extensive effects in
the liver providing evidence of distribution and metabolism. The changes
were seen in liver weight and at both macroscopic and microscopic
examination, the extent of the effects followed a dosage related trend.
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