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As of end June 2022 we have processed and published all dossiers that had been pending since 14 October 2021. While daily processing has resumed there remains a processing queue. New submissions will be at the back of the processing queue, and may be slightly delayed before publication. We appreciate your understanding in this matter.

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REACH - Registration, Evaluation, Authorisation and Restriction of Chemicals Regulation

Registered Substances Factsheets

Substances which have been registered and can be placed on the EEA market by those companies with a valid registration



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(RS)-3-Allyl-2-methyl-4-oxocyclopent-2- enyl (1R,3R)-2,2-dimethyl-3-(2-methyl prop-1-enyl)-cyclopropanecarboxylate (mixture of 2 isomers 1R trans: 1R/S only 1:3) (Esbiothrin)
807-421-6 260359-57-7 Active Full Joint ≥ 1 to < 10 tonnes 11-11-2020 View substance registered dossier
(S) (2Z,4E)-4-carboxy-11-methoxy-3,7,11-trimethyl-2,4-dodecadienoic acid disodium salt
918-890-2 - Active Intermediate Joint Intermediate use only 23-03-2018 View substance registered dossier
(S) 2-(Benzyloxycarbonylamino) 4-(neopentyloxysulfonyl)butyl thioacetate
873-888-8 1370348-26-7 Active Intermediate Joint Intermediate use only 27-09-2021 View substance registered dossier
(S)- 3-[4-(4,4,5,5-tetramethyl-[1,3,2] dioxaborolan-2-yl)-phenoxy]-pyrrolidine hydrochloride
948-439-5 2114341-27-2 Active Intermediate Joint Intermediate use only 29-07-2022 View substance registered dossier
(S)- 3[4-(4,4,5,5-tetramethyl-[1,3,2] dioxaborolan-2-yl)-phenoxyl]-pyrrolidine -1-carboxylic tert butyl ether
861-843-5 1383793-75-6 Active Intermediate Joint Intermediate use only 29-07-2022 View substance registered dossier
(S)-(+)-1-methoxy-2-propylamine
700-220-3 99636-32-5 Active Intermediate Individual Intermediate use only 30-09-2010 View substance registered dossier
(S)-(-)-1-(1-Naphthyl)ethylamine (2R,3R)-2,3-dihydroxybutanedioic salt
600-817-8 1073145-07-9 Active Intermediate Joint Intermediate use only 22-01-2018 View substance registered dossier
(S)-(-)-tetrahydro-2-furoic acid
433-770-5 - No longer Valid Intermediate Individual No longer valid 22-09-2011 View substance registered dossier
(S)-(-)-tetrahydro-2-furoic acid
433-770-5 - Active NONS Individual Tonnage data confidential 10-11-2008 View substance registered dossier
(S)-(4,5-dihydro-5-thioxo-1,3,4-thiadiazol-2-yl) benzenecarbothioate
257-581-0 51988-14-8 Active Full Joint ≥ 1 to < 10 tonnes 24-10-2019 View substance registered dossier
(S)-1,1-diphenyl-1,2-propanediol
443-220-6 46755-94-6 Cease Manufacture NONS Individual Cease manufacture 26-01-2012 View substance registered dossier
(S)-1,2,4-butanetriyltrimethanesulfonate
UK-164,608
433-850-1 99520-81-7 Active NONS Joint Tonnage data confidential 15-12-2008 View substance registered dossier
(S)-1,2-epoxypropane
240-241-0 16088-62-3 Active Intermediate Joint Intermediate use only 16-12-2010 View substance registered dossier
(S)-1-(3-Fluoro-propyl)-3-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenoxy]-pyrrolidine
950-570-8 2114341-28-3 Active Intermediate Joint Intermediate use only 29-07-2022 View substance registered dossier
(S)-1-[2-tert-butoxycarbonyl-3-(2-methoxyethoxy)propyl]-1-cyclopentanecarboxylic acid, cyclohexylamine salt
UK-81,786-57
425-510-4 167944-94-7 Active NONS Individual Tonnage data confidential 10-11-2008 View substance registered dossier
(S)-1-[3-(acetylthio)-2-methyl-1-oxopropyl]-L-proline
265-250-7 64838-55-7 Active Intermediate Joint Intermediate use only 22-03-2019 View substance registered dossier
(S)-1’- (tert-butyl)-2’-oxo-1’,2’,5,7-tetrahydrospiro[cyclopenta[b]pyridine-6,3’-pyrrolo[2,3-b]pyridine]-3-carboxylic acid
- - Active Intermediate Joint Intermediate use only 30-03-2022 View substance registered dossier
(S)-2'-oxo-1',2',5,7-tetrahydrospiro[cyclopenta[b]pyridine-6,3'-pyrrolo[2,3-b]-bipyridine]-3-carboxylic acid
- - Active Intermediate Joint Intermediate use only 06-07-2022 View substance registered dossier
(S)-2,2,3-trimethylcyclopent-3-ene-1-acetaldehyde
245-846-3 23727-15-3 Active Intermediate Joint Intermediate use only 07-12-2021 View substance registered dossier
(S)-2,2,4-trimethylpyrrolidine hydrochloride
943-629-4 1897428-40-8 Active Intermediate Joint Intermediate use only 16-07-2018 View substance registered dossier
Registrant/Supplier Address Country Registration Status Name EC / List no. CAS no. Last update year Details
ENDURA S.p.A. Viale Pietramellara, 5 40121 Bologna Italy Italy Active (RS)-3-Allyl-2-methyl-4-oxocyclopent-2- enyl (1R,3R)-2,2-dimethyl-3-(2-methyl prop-1-enyl)-cyclopropanecarboxylate (mixture of 2 isomers 1R trans: 1R/S only 1:3) (Esbiothrin) 807-421-6 260359-57-7 - View substance registered dossier
Bábolna Bioenvironmental Centre Ltd. Szállás u. 6. H-1107 Budapest Hungary Hungary Active (S) (2Z,4E)-4-carboxy-11-methoxy-3,7,11-trimethyl-2,4-dodecadienoic acid disodium salt 918-890-2 - - View substance registered dossier
ORGAPHARM Rue du Moulin de la Canne 45300 PITHIVIERS France France Active (S) 2-(Benzyloxycarbonylamino) 4-(neopentyloxysulfonyl)butyl thioacetate 873-888-8 1370348-26-7 - View substance registered dossier
sanofi chimie 82 avenue Raspail 94250 Gentilly France France Active (S)- 3-[4-(4,4,5,5-tetramethyl-[1,3,2] dioxaborolan-2-yl)-phenoxy]-pyrrolidine hydrochloride 948-439-5 2114341-27-2 - View substance registered dossier
ORGAPHARM Rue du Moulin de la Canne 45300 PITHIVIERS France France Active (S)- 3-[4-(4,4,5,5-tetramethyl-[1,3,2] dioxaborolan-2-yl)-phenoxy]-pyrrolidine hydrochloride 948-439-5 2114341-27-2 2020 View substance registered dossier
ORGAPHARM Rue du Moulin de la Canne 45300 PITHIVIERS France France Active (S)- 3[4-(4,4,5,5-tetramethyl-[1,3,2] dioxaborolan-2-yl)-phenoxyl]-pyrrolidine -1-carboxylic tert butyl ether 861-843-5 1383793-75-6 2020 View substance registered dossier
sanofi chimie 82 avenue Raspail 94250 Gentilly France France Active (S)- 3[4-(4,4,5,5-tetramethyl-[1,3,2] dioxaborolan-2-yl)-phenoxyl]-pyrrolidine -1-carboxylic tert butyl ether 861-843-5 1383793-75-6 - View substance registered dossier
BASF SE Carl-Bosch-Str. 38 67056 Ludwigshafen am Rhein Rheinland-Pfalz Germany Germany Active (S)-(+)-1-methoxy-2-propylamine 700-220-3 99636-32-5 2010 View substance registered dossier
Arran Chemical Company Ltd Monksland Industrial Estate N37DN24 Athlone Co. Roscommon Ireland Ireland Active (S)-(-)-1-(1-Naphthyl)ethylamine (2R,3R)-2,3-dihydroxybutanedioic salt 600-817-8 1073145-07-9 - View substance registered dossier
Carbogen Amcis Ltd 303 Clayton Lane M11 4SX Manchester Greater Manchester United Kingdom United Kingdom No longer Valid (S)-(-)-tetrahydro-2-furoic acid 433-770-5 - 2021 View substance registered dossier
Former NONS notifier unknown to ECHA - Contact the relevant UK competent national authority. - - Active (S)-(-)-tetrahydro-2-furoic acid 433-770-5 - - View substance registered dossier
[Confidential] - - - (S)-(4,5-dihydro-5-thioxo-1,3,4-thiadiazol-2-yl) benzenecarbothioate 257-581-0 51988-14-8 - View substance registered dossier
DSM Nutritional Products GmbH Emil-Barell-Str. 3 79639 Grenzach-Wyhlen Germany Germany Cease Manufacture (S)-1,1-diphenyl-1,2-propanediol 443-220-6 46755-94-6 2019 View substance registered dossier
Former NONS notifier unknown to ECHA - Contact the relevant UK competent national authority. - - Active (S)-1,2,4-butanetriyltrimethanesulfonate 433-850-1 99520-81-7 - View substance registered dossier
Labcorp Development SA 169 Parque Empresarial Las Tablas, Edificio 1 Calle Federico Mompou, 5 – 5 Planta 28050 Madrid Spain Spain Active (S)-1,2-epoxypropane 240-241-0 16088-62-3 - View substance registered dossier
ORGAPHARM Rue du Moulin de la Canne 45300 PITHIVIERS France France Active (S)-1-(3-Fluoro-propyl)-3-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenoxy]-pyrrolidine 950-570-8 2114341-28-3 - View substance registered dossier
sanofi chimie 82 avenue Raspail 94250 Gentilly France France Active (S)-1-(3-Fluoro-propyl)-3-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenoxy]-pyrrolidine 950-570-8 2114341-28-3 - View substance registered dossier
Former NONS notifier unknown to ECHA - Contact the relevant French competent national authority. - - Active (S)-1-[2-tert-butoxycarbonyl-3-(2-methoxyethoxy)propyl]-1-cyclopentanecarboxylic acid, cyclohexylamine salt 425-510-4 167944-94-7 - View substance registered dossier
QUIMICA SINTETICA, S.A. C/ Dulcinea, s/n 28805 Alcalá de Henares Madrid Spain Spain Active (S)-1-[3-(acetylthio)-2-methyl-1-oxopropyl]-L-proline 265-250-7 64838-55-7 2018 View substance registered dossier
FARMHISPANIA S.A. Passeig del Riu Besós, 9-10 08160 Montmeló Barcelona Spain Spain Active (S)-1-[3-(acetylthio)-2-methyl-1-oxopropyl]-L-proline 265-250-7 64838-55-7 2019 View substance registered dossier
L.C.M. TRADING SPA via Mazzini 33 20099 Sesto San Giovanni Lombardia Italy Italy Active (S)-1-[3-(acetylthio)-2-methyl-1-oxopropyl]-L-proline 265-250-7 64838-55-7 - View substance registered dossier
AbbVie Srl S.R. 148 Pontina Km 52 snc 04011 Campoverde di Aprilia (LT) Italy Italy Active (S)-1’- (tert-butyl)-2’-oxo-1’,2’,5,7-tetrahydrospiro[cyclopenta[b]pyridine-6,3’-pyrrolo[2,3-b]pyridine]-3-carboxylic acid - - - View substance registered dossier
AbbVie Srl S.R. 148 Pontina Km 52 snc 04011 Campoverde di Aprilia (LT) Italy Italy Active (S)-2'-oxo-1',2',5,7-tetrahydrospiro[cyclopenta[b]pyridine-6,3'-pyrrolo[2,3-b]-bipyridine]-3-carboxylic acid - - - View substance registered dossier
LES DERIVES RESINIQUES ET TERPENIQUES 30 rue Gambetta B.P. 206 40105 Dax Cedex France France Active (S)-2,2,3-trimethylcyclopent-3-ene-1-acetaldehyde 245-846-3 23727-15-3 2021 View substance registered dossier
Esteve Quimica, S.A. Torre Esteve Passeig de la Zona Franca, 109, 4ª Planta 08038 Barcelona Barcelona Spain Spain Active (S)-2,2,4-trimethylpyrrolidine hydrochloride 943-629-4 1897428-40-8 - View substance registered dossier

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