7-Isopropyl-2H,4H-1,5-benzodioxepin-3-one

Vapour pressure

Link to relevant study record(s)

Reference

Endpoint:

vapour pressure

Type of information:

experimental study

Adequacy of study:

key study

Study period:

From August 07 to 12, 2009

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Remarks:

The study was conducted according to an internationally recognised method, and under GLP. No deviation was reported. Test substance is adequately specified with purity. Therefore full validation applies.

Qualifier:

according to guideline

Guideline:

OECD Guideline 104 (Vapour Pressure Curve)

Version / remarks:

March 23, 2006

Deviations:

no

Qualifier:

according to guideline

Guideline:

EU Method A.4 (Vapour Pressure)

Version / remarks:

Regulation (EC) No. 440/2008

Deviations:

no

Principles of method if other than guideline:

Not applicable

GLP compliance:

yes (incl. QA statement)

Remarks:

Swiss GLP compliance programme (inspected on November 5 to 9 and 26 to 30, 2007 / signed on November 12, 2008)

Type of method:

gas saturation method

Specific details on test material used for the study:

Storage condition of test material: In the refrigerator at about 5 °C, in the dark, under Nitrogen

Key result

Temp.:

25 °C

Vapour pressure:

0.178 Pa

The experimental results lead to the conclusion that the vapour pressure of the test item is:

1.4 x 10^-2 Pa at 5 °C

4.8 x 10^-2 Pa at 15 °C

1.9 x 10^-1 Pa at 25 °C

Calculation of the vapour pressure of test item at 25 °C by interpolation based upon the simplified Clausius-Clapeyron equation resulted in a vapour pressure of 1.8 x 10^-1 Pa.

 

 

The trapping efficiency of the test item in the first cooling trap was very good. Between 99.7% and 100% of the test item was trapped in the first cooling trap.

 

Table 4.6/1: Data of the vapour pressure curve for test item

T [°C]	1/T [Kelvin]	ln Pvp
5	0.00359	-4.31
	0.00359	-4.26
	0.00359	-4.24
15	0.00347	-2.96
	0.00347	-3.24
	0.00347	-2.96
25	0.00335	-1.67
	0.00335	-1.70
	0.00335	-1.61

 

The tabulated results represent rounded-off values obtained by calculations based on the exact

raw data.

Y = b · x + a with Y = ln (Pvp mean in Pa)

x = 1/T (Kelvin)

b = -10744.86 (slope)

a = 34.31 (y-axis intercept)

r2 = 0.991389

Calculated vapor pressure of test item at 25 °C: 1.78 x 10^-1 Pa

See the attached document for figure "Vapour Pressure Curve of test item"

Conclusions:

Low volatility (based on volatility bands criteria for occupational exposure (Chesar / ECETOC TRA), << 500 Pa).

Executive summary:

The vapour pressure of the test substance was measured under GLP according to OECD 104 / EU A4 guideline, gas saturation method. Determinations were conducted at 5, 15 and 25 °C, with three flow rates per temperature. Mass of evaporated test item was quantified by HPLC. Vapour pressure at 25 °C was interpolated from the regression.

The vapour pressure of test substance at 25 °C was interpolated from the vapour pressure curve and was calculated to be 1.78 x 10^-1 Pa.

Description of key information

Low volatility.

Key value for chemical safety assessment

Vapour pressure:

0.178 Pa

at the temperature of:

25 °C

Additional information

A fully reliable experimental study, conducted according to a recognized OECD/EC method and under GLP, is available. Therefore, it is considered as a key study, and the result is retained as key data.