Registration Dossier
Registration Dossier
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EC number: 700-343-2 | CAS number: -
Guidance on Safe Use
Administrative data
First-aid measures
First-aid measures for the on-site isolated intermediate are assumed to be the same as for 2,4-diisocyanato-1-methylbenzene and 1,3-diisocyanato-2-methylbenzene. The following is used for the safety procedures at the production site and can typically be found on an SDS of 2,4-diisocyanato-1-methylbenzene/1,3-diisocyanato-2-methylbenzene:
General
Take proper precautions to ensure your own health and safety before attempting rescue and providing first aid. Prompt action is essential. Assess rapidly and aggressively. Resuscitation may be indicated.
Skin
Immediately remove contaminated clothing. Wash skin thoroughly with mild soap and water. Flush with lukewarm water for 15 minutes. If sticky, use waterless cleaner first. Obtain emergency medical attention.
Inhalation
If overcome by exposure, remove victim to fresh air immediately. Give oxygen or artificial respiration as needed. Obtain emergency medical attention.
Eye
Immediately flush the eyes with large amounts of clean low-pressure water for at least 15 minutes, occasionally lifting the upper and lower lids. If pain or irritation persists, promptly obtain medical attention.
Ingestion
Do not induce vomiting because of possible severe irritant side effects. Obtain emergency medical attention.
Note to Physician
Treat symptomatically. Treatment of overexposure should be directed at the control of symptoms and the clinical condition of the patient.
Fire-fighting measures
Fire-fighting measures for the on-site isolated intermediate are assumed to be the same as for 2,4-diisocyanato-1-methylbenzene and 1,3-diisocyanato-2-methylbenzene.The following is used for the safety procedures at the production site and can typically be found on an SDS of 2,4-diisocyanato-1-methylbenzene/1,3-diisocyanato-2-methylbenzene:
Suitable extinguishing media: CO2, foam, dry powder; in cases of larger fires, water spray should be used. In case of fire, formation of carbon monoxide, nitrogen oxide, isocyanate vapour, and traces of hydrogen cyanide is possible. Firemen have to wear self−contained breathing apparatus. Do not let enter contaminated extinguishing water into the soil, groundwater or surface waters.
Unsuitable extinguishing media: Most foams will react with the material and release corrosive/toxic gases.
Protection of Firefighters
Protective Equipment/Clothing:
Wear positive pressure self-contained breathing apparatus (SCBA). Wear chemical protective clothing that is specifically recommended by the manufacturer. It may provide little or no thermal protection. Structural firefighters' protective clothing is recommended for fire situations ONLY; it is not effective in spill situations.
Fire Fighting Guidance:
On exposure to high temperature, may decompose, releasing toxic/flammable vapors. When mixed with air and exposed to ignition source, vapors can burn in open or explode if confined. Vapors may be heavier than air. May travel long distances along the ground before igniting and flashing back to vapor source. Under fire conditions, highly hazardous fumes will be present. Use water with care on closed containers - material will react with water/generate pressure/may explode/spread fire/increase risk of burns/injuries/contact with hazardous material. Liquid heavier than water. Blanket with alcohol-resistant foam. Note: Most foams will react with the material and release corrosive/toxic gases. Byproduct of water reaction may be harmful - minimize exposure to water contacting this material. When fighting a fire, notify environmental authorities if liquid runoff enters sewers or public waters.
Hazardous Combustion Products:
During instances of thermal decomposition or combustion, the liberation of diisocyanate vapors and other irritating, highly toxic gases may be generated and/or released. Traces of hydrogen cyanide.
Accidental release measures
Accidental release measures for the on-site isolated intermediate are assumed to be the same as for 2,4-diisocyanato-1-methylbenzene and 1,3-diisocyanato-2-methylbenzene.The following is used for the safety procedures at the production site and can typically be found on an SDS of 2,4-diisocyanato-1-methylbenzene/1,3-diisocyanato-2-methylbenzene:
Release Response
Highly reactive material. May release toxic materials/contaminate water supplies/create human health hazard. Liquids/vapors may ignite. Equip responders with proper protection. Use self-contained breathing apparatus and body-covering protective clothing. Evacuate/limit access. Extinguish ignition sources; stop release; prevent flow to sewers or public waters. Blanket with alcohol-resistant foam. Impound/recover large land spill; soak up small spill with inert solids. Avoid water for clean-up or use in large quantities due to reactivity. Use suitable disposal containers. Reacts with water, releasing CO2, forming urea polymers. Contain/collect rapidly to minimize dispersion. Disperse residue to reduce aquaticharm. Report per regulatory requirements. Notify fire and environmental authorities.
Handling and storage
Handling and storage for the on-site isolated intermediate are assumed to be the same as for 2,4-diisocyanato-1-methylbenzene and 1,3-diisocyanato-2-methylbenzene. The following is used for the safety procedures at the production site and can typically be found on an SDS of 2,4-diisocyanato-1-methylbenzene/1,3-diisocyanato-2-methylbenzene:
Handling
Use special care when handling/transporting samples. Store at 20-24°C. Material sampling procedures should avoid vapor inhalation and skin/eye contact and only be conducted with proper protective equipment. All containers should be labeled to warn against exposure. Handle empty containers with care - residue may be combustible. When cleaning or repairing equipment contaminated with this material, total encapsulating impervious protective suits, gloves, and boots should be worn to prevent any contact. A positive pressure self-contained breathing apparatus and/or a supplied air respirator should be used. Decontaminate empty, non-returnable isocyanate drums by filling with water. Allow to stand 48 hours with bung removed. After 48 hours, drain and pierce drums. Wash with sodium carbonate solution (5-10%).
Storage
All containers should be labeled to warn against exposure. Store in tightly closed/properly vented containers with vents directed to locations removed from potential personnel exposure. Store in well ventilated area away from water, moisture, humidity, and direct sunlight. Store at 20-24°C. Do not store in galvanized or other corrodible containers. Storage and handling in stainless steel is preferred. Storage in polyethylene containers is hazardous because of absorption of water through the plastic.
Transport information
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Marine transport (UN RTDG/IMDG)
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Exposure controls / personal protection
Exposure controls/personal protection for the on-site isolated intermediate are assumed to be the same as for 2,4-diisocyanato-1-methylbenzene and 1,3-diisocyanato-2-methylbenzene. The following is used for the safety procedures at the production site and can typically be found on an SDS of 2,4-diisocyanato-1-methylbenzene/1,3-diisocyanato-2-methylbenzene:
Threshold value in air defined by TRGS 900 (MAK value):2,4−/2,6−di−isocyanatotoluene 0,01 ml/m³ (ppm) corresp. to 0,07 mg/m³
CAS No.: 584−84−9/91−08−7 (eight hours average value) maximum limit of excess factor 1. The maximum allowable concentration for TDI is below the threshold for perception of the odour. Wear suitable protective clothing, protective gloves and protective goggles/mask. Suitable materials for safety gloves:
Butyl rubber − IIR (>= 0.5 mm)
Fluorinated rubber − FKM (>= 0.4 mm)
Respiratory protection required in insufficiently ventilated working areas. An air−fed mask, or for short periods of work, a combination of charcoal
filter and particulate filter is recommended. A smell of TDI is evidence that the maximum air concentration has been significantly exceeded. The
area of exposure is to be evacuated immediately. In case of hypersensitivity of the respiratory tract (e.g. asthmatics and those who suffer from chronic bronchitis) it is inadvisable to work with the product. Symptoms affecting the respiratory tract can also occur several hours after overexposure. Keep away from foodstuffs, drinks and tobacco. Wash hands before breaks and at end of work. Keep working clothes separate. Take off immediately all contaminated clothing.
Stability and reactivity
Stability and reactivity for the on-site isolated intermediate are assumed to be the same as for 2,4-diisocyanato-1-methylbenzene and 1,3-diisocyanato-2-methylbenzene. The following is used for the safety procedures at the production site and can typically be found on an SDS of 2,4-diisocyanato-1-methylbenzene/1,3-diisocyanato-2-methylbenzene:
Thermal decomposition: No decomposition below initial boiling point. Hazardous decomposition products: No hazardous decomposition products when stored and handled correctly. Hazardous reactions: Exothermic reaction with amines and alcohols; reacts with water forming
CO2, in closed containers risk of bursting owing to increase of pressure.
Disposal considerations
Disposal considerations for the on-site isolated intermediate are assumed to be the same as for 2,4-diisocyanato-1-methylbenzene and 1,3-diisocyanato-2-methylbenzene. The following is used for the safety procedures at the production site and can typically be found on an SDS of 2,4-diisocyanato-1-methylbenzene/1,3-diisocyanato-2-methylbenzene:
The relevant EU Directives and local, regional and national regulations must be complied with. May be incinerated in a suitable facility provided local regulations are observed. For disposal within the EC, the appropriate code according to the European Waste Catalogue (EWC) should be used. After final product withdrawal, all residues must be removed from containers (drip−free, powder−free or paste−free). Once the product residues adhering to the walls of the containers have been rendered harmless, the product and hazard labels must be invalidated. Containers must be recycled
in compliance with national legislation and and environmental regulations.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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