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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
short-term toxicity to fish
Type of information:
experimental study
Adequacy of study:
key study
Study period:
feb 2010
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2010
Report date:
2010

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to guideline
Guideline:
OECD Guideline 203 (Fish, Acute Toxicity Test)
Qualifier:
according to guideline
Guideline:
EU Method C.1 (Acute Toxicity for Fish)
GLP compliance:
yes (incl. QA statement)

Test material

Constituent 1
Chemical structure
Reference substance name:
(±)-7-[(3-chloro-6,11-dihydro-6-methyldibenzo[c,f][1,2]thiazepin-11-yl)amino]heptanoic acid S,S-dioxide
EC Number:
276-851-9
EC Name:
(±)-7-[(3-chloro-6,11-dihydro-6-methyldibenzo[c,f][1,2]thiazepin-11-yl)amino]heptanoic acid S,S-dioxide
Cas Number:
72797-41-2
Molecular formula:
C21H25ClN2O4S
IUPAC Name:
(±)-7-[(3-chloro-6,11-dihydro-6-methyldibenzo[c,f][1,2]thiazepin-11-yl)amino]heptanoic acid S,S-dioxide
Test material form:
solid: crystalline
Details on test material:
White powder
Specific details on test material used for the study:
Batch 562371/016 - 100% purity -

Sampling and analysis

Analytical monitoring:
no

Test organisms

Test organisms (species):
Danio rerio (previous name: Brachydanio rerio)
Details on test organisms:
Variety : Hamilton-BuchananAge : sexually immature young fish , lenght 2 +/- 1 cm
Supplier : Dehner Garten-Center, D.67433 Neustadt
Date of arrival : Jan 21st 2010
Before being used for the test, the fish were kept for 14 days under test conditions. During this period, mortality didn't surpass 5%.

Study design

Test type:
static
Water media type:
freshwater
Limit test:
no
Total exposure duration:
96 h
Post exposure observation period:
24/ 48/ 72: 96 hours

Test conditions

Test temperature:
24.2- 25.2°C
pH:
7.5 - 8.1
Dissolved oxygen:
7.3 mg/L or 82.5%
Nominal and measured concentrations:
nominal : 1/ 10 / 100 mg/L
Reference substance (positive control):
no

Results and discussion

Effect concentrationsopen allclose all
Key result
Duration:
96 h
Dose descriptor:
LC50
Effect conc.:
> 100 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
mortality (fish)
Duration:
96 h
Dose descriptor:
NOEC
Effect conc.:
ca. 100 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Details on results:
The mortality in the control may not exceed 1 fish at the end of the test. No mortalities occurred in the
control.
Reported statistics and error estimates:
The validity criteria were met

Applicant's summary and conclusion

Validity criteria fulfilled:
yes
Conclusions:
According the guideline OECD 203, the following results for the test item 1574 ACIDE could be determined : 96h NOEC = 100 mg/L and 96h LC50 >100 mg/L
Executive summary:

The toxicity against Danio rerio was tested using a static test design.

The main study was performed using three concentrations ranging from 1 to 100 mg/L.

Treatments and control showed no mortality

The following results for the test item 1574 Acide could be determined : 96h NOEC = 100 mg/L and

96h LC50 >100 mg/L