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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

Key value for chemical safety assessment

Acute toxicity: via oral route

Link to relevant study records
Reference
Endpoint:
acute toxicity: oral
Type of information:
read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
weight of evidence
Reason / purpose for cross-reference:
read-across source
Reason / purpose for cross-reference:
read-across source
Reason / purpose for cross-reference:
read-across source
Reason / purpose for cross-reference:
read-across source
Reason / purpose for cross-reference:
read-across source
Reason / purpose for cross-reference:
read-across source
Reason / purpose for cross-reference:
read-across: supporting information
Key result
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 39 255 mg/kg bw
Based on:
test mat.
Interpretation of results:
GHS criteria not met
Conclusions:
Based on the data of 6 different structurally-related substances 2-dodecylhexadecan-1-ol is practically nontoxic after oral administration to rats.
Endpoint conclusion
Endpoint conclusion:
no adverse effect observed
Dose descriptor:
LD50
Value:
32 200 mg/kg bw

Acute toxicity: via inhalation route

Endpoint conclusion
Endpoint conclusion:
no study available

Acute toxicity: via dermal route

Link to relevant study records
Reference
Endpoint:
acute toxicity: dermal
Type of information:
read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
weight of evidence
Reason / purpose for cross-reference:
read-across source
Reason / purpose for cross-reference:
read-across source
Key result
Sex:
male/female
Dose descriptor:
LD0
Effect level:
>= 2 mL/kg bw
Based on:
test mat.
Interpretation of results:
GHS criteria not met
Conclusions:
Based on the data of two structurally-related substances 2-dodecylhexadecan-1-ol is considered to be practically nontoxic after dermal application to rabbits.
Endpoint conclusion
Endpoint conclusion:
no adverse effect observed
Dose descriptor:
discriminating dose
Value:
1 674 mg/kg bw

Additional information

Experimental studies of 6 representatives of the category of Guerbet alcohols show a very low acute oral toxicity. Mortalities were only observed after application of the shortest chain Guerbet alcohol 2 -Butyl-octan-1-ol (C12) but only at doses of about 15,000 mg/kg bw and above. No clinical symptoma were observed for Alcohols C16 -20, branched and longer chain guerbet alcohols after application of very high doses. No pathological findings were observed at dissection of the animals.

Acute dermal toxicity studies of C16 and C20 Guerbet alcohol also show a low dermal toxicity at doses of up to 2 ml/kg. The test substances were applied on intact as well as on scarificed skin with a damaged skin barrier. No deaths occurred at any of the doses applied. In case of the experiment with scarificed skin it should be considered that doses systemically available were actually much higher.

Based on the available data it can be concluded that all Guerbet alcohols of the category are of very low acute oral and dermal toxicity.

Justification for classification or non-classification

Available data are conclusive but not sufficient for classification of 2 -dodecylhexadecan-1-ol with regard to acute toxicity.