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EC number: 225-625-8 | CAS number: 4979-32-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
DCBS showed only very slight and transient skin and eye irritation in guideline studies performed according to GLP with rabbits (Monsanto Co. 1985).
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP and guideline study
- Qualifier:
- according to guideline
- Guideline:
- EPA OPP 81-5 (Acute Dermal Irritation)
- Principles of method if other than guideline:
- Method: other: exposure time: 24 h (no further data)
- GLP compliance:
- yes
- Species:
- rabbit
- Strain:
- New Zealand White
- Type of coverage:
- occlusive
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Duration of treatment / exposure:
- 4 and 24 h
- Observation period:
- up to 72 h
- Number of animals:
- 6
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: score = 0 at any time point
- Remarks on result:
- other: 4 h treatment
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: score = 0 at any time point
- Remarks on result:
- other: 4 h treatment
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0.1
- Max. score:
- 4
- Reversibility:
- fully reversible
- Remarks on result:
- other: 24 h treatment
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: score = 0 at any time point
- Remarks on result:
- other: 24 h treatment
- Irritation parameter:
- primary dermal irritation index (PDII)
- Basis:
- mean
- Time point:
- other: 24, 48, 72 h
- Score:
- 0
- Max. score:
- 8
- Reversibility:
- other: 4 h treatment no effects
- Remarks on result:
- other: 4 h treatment
- Irritation parameter:
- primary dermal irritation index (PDII)
- Basis:
- mean
- Time point:
- other: 24, 48, 72 h
- Score:
- 0.1
- Max. score:
- 8
- Reversibility:
- fully reversible within: 7 d
- Remarks on result:
- other: 24 h treatment
- Interpretation of results:
- GHS criteria not met
- Executive summary:
In a GLP and EPA Guideline study with New Zealand White rabbits, the dermal application of 0.5 g of the solid test substance DCBS to 6 animals for 4 and 24 hours was essentially non-irritating to the skin. The only irritation seen was transient very slight (barely perceptible) erythema in one animal at the sites exposed for 24 hours under occlusive covering. This animal was free of irritation at both sites by day 7. The primary irritation index for the 24 -hour exposures was 0.1 (Monsanto Co. 1985).
Reference
The test substance DCBS was essentially non-irritating to the skin. The only irritation seen was transient very slight (barely perceptible) erythema in one animal at the sites exposed for 24 hours under occlusive covering. This animal was free of irritation at both sites by day 7. The primary irritation index for the 24 -hour exposures was 0.1.
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP and guideline study
- Qualifier:
- according to guideline
- Guideline:
- EPA OPP 81-4 (Acute Eye Irritation)
- GLP compliance:
- yes
- Species:
- rabbit
- Strain:
- New Zealand White
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Duration of treatment / exposure:
- 24 h
- Observation period (in vivo):
- 24, 48, 72 h and 7 d after treatment
- Number of animals or in vitro replicates:
- 6
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- other: slight effects 1 h after treatment
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 3
- Reversibility:
- fully reversible within: 24 h
- Remarks on result:
- other: slight effects 1h after treatment
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: no effects
- Remarks on result:
- other: no effects
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 2
- Reversibility:
- fully reversible within: 72 h
- Remarks on result:
- other: *1/6 animal with (+) grade at 24 and 48 h, reversible within 72 h
- Interpretation of results:
- GHS criteria not met
- Executive summary:
In a GLP and EPA guideline study with six New Zealand White rabbits, a single application of 0.1cc DCBS in the lower conjunctivial sac of the right eye produced only mild and transient ocular irritation, consisting primarily of mild conjunctivial irritation (redness, chemosis and/or discharge) and iridial changes, with most severe effects occurring at one hour. All animals were free of ocular irritation within 24 hours to 7 days after instillation of the test material (Monsanto Co. 1985).
Reference
DCBS produced only mild, transient ocular irritation, consisting primarily of mild conjunctivial irritation (redness, chemosis and/or discharge) and iridial changes, with most severe effects occurring at one hour. No responses considered to be positive under the reference regulations were seen. All animals were free of ocular irritation within 24 hours to 7 days after instillation of the test material.
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Additional information
Skin
Non-human information
In a GLP and EPA Guideline study with New Zealand White rabbits, the dermal application of 0.5 g of the solid test substance DCBS to 6 animals for 4 and 24 hours was essentially non-irritating to the skin. The only irritation seen was transient very slight (barely perceptible) erythema in one animal at the sites exposed for 24 hours under occlusive covering. This animal was free of irritation at both sites by day 7. The primary irritation index for the 4 h-hour exposure was 0 and for the 24 -hour exposures 0.1 (Monsanto Co. 1985).
Eye
Non-human information
In a GLP and EPA guideline study with six New Zealand White rabbits, a single application of 100 mg DCBS in the lower conjunctivial sac of the right eye produced only mild and transient ocular irritation, consisting primarily of mild conjunctivial irritation (redness, chemosis and/or discharge) and iridial changes, with most severe effects occurring at one hour. All animals were free of ocular irritation within 24 hours to 7 days after instillation of the test material (Monsanto Co. 1985).
Justification for classification or non-classification
No classification is required according to the classification of regulation no. 1272/2008 (GHS).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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