Registration Dossier
Registration Dossier
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EC number: 222-883-3 | CAS number: 3648-18-8
Partition coefficient
Administrative data
Link to relevant study record(s)
Description of key information
The calculated estimate of Log Pow was 9.26 for the read across substance DOTO.
In accordance with Section 2, Annex XI of Regulation (EC) No. 1907/2006 (REACH), the study required under point 7.8 of Annex VIII does not need to be conducted if testing is not technically feasible. In the submitted hydrolysis study (Lange, 2012a) the test material DOTL was determined to be hydrolytically unstable at pH 4, 7 and 9, with a half life of less than 4.5 hours. The test material was observed to immediately hydrolyse to dioctyltin oxide (insoluble) and lauric acid in the presence of water. Based on these findings, testing for this endpoint is not technically possible.
Key value for chemical safety assessment
- Log Kow (Log Pow):
- 9.26
Additional information
In the submitted hydrolysis study (Lange, 2012a) the test material DOTL was determined to be hydrolytically unstable at pH 4, 7 and 9, with a half life of less than 4.5 hours. The test material was observed to immediately hydrolyse to dioctyltin oxide (insoluble) and lauric acid in the presence of water. Based on these findings, testing for this endpoint is not technically possible. As no experimental determination of the partition coefficient was possible, a computer estimate calculation was performed using KOWWIN v1.68 (Sept 2010) 2000 U.S. Environmental Protection Agency. A reliability score of 3 was assigned, in accordance with the criteria for assigning data quality in line with the principles described by Klimisch (1997) due to the lack of validation for organometallics in these calculations.
The calculated estimate of Log Pow was 9.26.
Two disregarded studies (Recommendation for classification dossier (2005) and IUCLID Data Set (2006)) were included for completeness as both are in the public domain, the studies were deemed unsuitable as the result was derived using calculation software not validated for organometallic substances reported in secondary sources.
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