Brief Profile

The Brief Profile summarizes the non-confidential data on substances as it is held in the databases of the European Chemicals Agency (ECHA), including data provided by third parties. The Brief Profile is automatically generated; note that it does not currently distinguish between harmonised classification and minimum classification; information requirements under different legislative frameworks may therefore not be fully up to date or complete. For accuracy reasons, substance manufacturers and imports have the responsibility to consult official sources, e.g. the electronic edition of the Official Journal of the European Union.
This Brief Profile is covered by the ECHA Legal Notice.

Substance Description

Substance identity

EC / List no.:
200-431-6
CAS no.:
59-50-7
Index number:
Molecular formula:
C7H7ClO
SMILES:
CC1=CC(O)=CC=C1Cl
InChI:
InChI=1S/C7H7ClO/c1-5-4-6(9)2-3-7(5)8/h2-4,9H,1H3
Type of substance:
Mono constituent substance
Origin:
Organic
Registered compositions:
5
Of which contain:
0 impurities relevant for classification
0 additives relevant for classification
Substance Listed:
EINECS (European INventory of Existing Commercial chemical Substances) List

Hazard classification & labelling

Danger! According to the harmonised classification and labelling (ATP13) approved by the European Union, this substance causes severe skin burns and eye damage, is very toxic to aquatic life, is harmful if swallowed, causes serious eye damage, is harmful to aquatic life with long lasting effects, may cause an allergic skin reaction and may cause respiratory irritation.

Additionally, the classification provided by companies to ECHA in REACH registrations identifies that this substance is harmful in contact with skin.

Breakdown of all 976 C&L notifications submitted to ECHA

Aquatic Acute 1 H400 Harmonised Classification
Acute Tox. 4 H302 Harmonised Classification
Eye Dam. 1 H318 Harmonised Classification
Acute Tox. 4 H312
Skin Sens. 1 H317
Skin Corr. 1C H314 Harmonised Classification
Aquatic Chronic 3 H412 Harmonised Classification
STOT SE 3 H335 Harmonised Classification
Skin Sens. 1B H317 Harmonised Classification
Skin Corr. 1B H314
0% 10% 20% 30% 40% 50% 60% 70% 80% 90% 100%

https://www.echa.europa.eu/diss-blank-theme/images/cnl/graph/tick.png Harmonised Classification

https://www.echa.europa.eu/diss-blank-theme/images/cnl/graph/Reach.png REACH registration dossiers notifications

https://www.echa.europa.eu/diss-blank-theme/images/cnl/graph/CLP.png CLP notifications

Properties of concern

  • Ss
Officially recognised in the EU as Skin sensitising ( Harmonised C&L).
  • Ss
There is broad agreement in that a majority of data submitters agree this substance is Skin sensitising (100% of REACH registrations).

Regulatory activities

Registration, Evaluation, Authorisation & Restriction of Chemicals (REACH)

Registration
Pre-registration:
Substance pre-registered under REACH.
Registration:
This substance has 3 active registrations under REACH, 1 Joint Submission(s) and 0 Individual Submission(s).
Please see Registrants/Suppliers details.
Evaluation
Dossier Evaluation:
Substance Evaluation:
Authorisation
Candidate List:
Annex XIV (Authorisation List):
Restriction
Annex XVII (Restriction List):

Classification Labelling & Packaging (CLP)

Harmonised C&L:
A European Union Harmonised Classification & Labelling has been assigned to this substance.
Notification:
Classification & Labelling has been notified by industry to ECHA for this substance.

Biocidal Products Regulation (BPR)

Active Substance:
This substance is approved for use as a Biocidal Active Substance
Biocidal Products:
There are 0 authorised Biocidal Product(s) that use this substance as an active ingredient

Prior Informed Consent (PIC)

Annex I:
Annex V:

European Union Observatory for Nanomaterials (EUON)

EUON:

About this substance

This substance is manufactured and/or imported in the European Economic Area in 1 - 10 tonnes per year.

This substance is used by consumers, by professional workers (widespread uses), in formulation or re-packing, at industrial sites and in manufacturing.

This substance is approved for use as a biocide in the EEA and/or Switzerland, for: human hygiene, disinfection, veterinary hygiene, product preservation, preservation of fibres, leather, rubber, or polymers, preservation for working / cutting fluids.

This substance is used in the following products: cosmetics and personal care products.

Other release to the environment of this substance is likely to occur from: indoor use.

ECHA has no public registered data on the use of this substance in activities or processes at the workplace.

ECHA has no public registered data on the routes by which this substance is most likely to be released to the environment.

ECHA has no public registered data indicating whether or into which articles the substance might have been processed.

This substance is used in the following products: pH regulators and water treatment products, laboratory chemicals and polishes and waxes.

This substance is used in the following areas: formulation of mixtures and/or re-packaging, health services and scientific research and development. This substance is used for the manufacture of: chemicals.

This substance is used in the following activities or processes at workplace: transfer of chemicals, closed processes with no likelihood of exposure, closed, continuous processes with occasional controlled exposure, closed batch processing in synthesis or formulation, batch processing in synthesis or formulation with opportunity for exposure, mixing in open batch processes, transfer of substance into small containers, treatment of articles by dipping and pouring and laboratory work.

Other release to the environment of this substance is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners).

This substance is used in the following products: metals, coating products, fillers, putties, plasters, modelling clay and fuels.

This substance is used in the following activities or processes at workplace: closed batch processing in synthesis or formulation, mixing in open batch processes, closed processes with no likelihood of exposure, closed, continuous processes with occasional controlled exposure, batch processing in synthesis or formulation with opportunity for exposure and laboratory work.

Release to the environment of this substance can occur from industrial use: formulation of mixtures.

This substance is used in the following products: textile treatment products and dyes, pH regulators and water treatment products, non-metal-surface treatment products, inks and toners, leather treatment products and polymers. This substance has an industrial use resulting in manufacture of another substance (use of intermediates).

This substance is used in the following areas: formulation of mixtures and/or re-packaging and printing and recorded media reproduction. This substance is used for the manufacture of: chemicals, textile, leather or fur, plastic products and mineral products (e.g. plasters, cement).

This substance is used in the following activities or processes at workplace: transfer of chemicals, closed processes with no likelihood of exposure, closed batch processing in synthesis or formulation, closed, continuous processes with occasional controlled exposure, batch processing in synthesis or formulation with opportunity for exposure, mixing in open batch processes and transfer of substance into small containers.

Release to the environment of this substance can occur from industrial use: as processing aid, as an intermediate step in further manufacturing of another substance (use of intermediates), in processing aids at industrial sites and as processing aid.

This substance is used in the following activities or processes at workplace: transfer of chemicals, closed processes with no likelihood of exposure, closed batch processing in synthesis or formulation, transfer of substance into small containers, laboratory work, closed, continuous processes with occasional controlled exposure, batch processing in synthesis or formulation with opportunity for exposure, mixing in open batch processes and manual maintenance (cleaning and repair) of machinery.

Release to the environment of this substance can occur from industrial use: manufacturing of the substance.

ECHA has no data from registration dossiers on the precautionary measures for using this substance. Guidance on the safe use of the substance provided by manufacturers and importers of this substance.

Registrants/suppliers

  • Lanxess Deutschland GmbH, Kennedyplatz 1 50569 Köln Germany
  • SIGMA-ALDRICH CHEMIE GMBH, Riedstrasse 2 89555 Steinheim Germany
  • Sustainability Support Services (Europe) AB, Markaskälsvägen 6 22647 Lund Sweden

Substance names and other identifiers

4-chloro-3-methylphenol
EU. Dangerous Substances - Eco-Labels
4-chloro-m-cresol
EU. Dangerous Substances - Eco-Labels
chlorocresol; 4-chloro-m-cresol; 4-chloro-3-methylphenol
EU. Worker Protection-Hazardous (98/24), EU. Workplace Signs, EU. Hazardous Waste Properties: Annex III (2008/98/EC), EU. Young People at Work (94/33)
chlorocresol;4-chloro-m-cresol;4-chloro-3-methylphenol
C&L Inventory
4-chlor-3-methylfenol (cs)
C&L Inventory
4-Chlor-3-methylphenol (de)
C&L Inventory
4-chlor-3-metilfenolis (lt)
C&L Inventory
4-Chlor-m-kresol (de)
C&L Inventory
4-chlor-m-krezolis, (lt)
C&L Inventory
4-chloro-3-metylofenol (pl)
C&L Inventory
4-chloro-3-méthylphénol (fr)
C&L Inventory
4-chloro-m-crésol (fr)
C&L Inventory
4-chloro-m-krezol (pl)
C&L Inventory
4-chlór-3-metylfenol (sk)
C&L Inventory
4-chlór-meta-krezol (sk)
C&L Inventory
4-clor-3-metilfenol (ro)
C&L Inventory
4-clor-m-cresol (ro)
C&L Inventory
4-cloro-3-metilfenol (es)
C&L Inventory
4-cloro-m-cresol (es)
C&L Inventory
4-hlor-3-metilfenols (lv)
C&L Inventory
4-hlor-m-krezols (lv)
C&L Inventory
4-kloori-3-metyylifenoli (fi)
C&L Inventory
4-klor-3-metylfenol (no)
C&L Inventory
4-klor-m-kresol (no)
C&L Inventory
4-kloro-3-metil-fenol (hr)
C&L Inventory
4-kloro-3-metilfenol (sl)
C&L Inventory
4-kloro-3-metüülfenool (et)
C&L Inventory
4-kloro-m-kresool (et)
C&L Inventory
4-kloro-m-krezol (hr)
C&L Inventory
4-klór-3-metilfenol (hu)
C&L Inventory
4-klór-m-krezol (hu)
C&L Inventory
4-хлоро-3-метилфенол (bg)
C&L Inventory
4-хлоро-m-крезол (bg)
C&L Inventory
Chloorkresol (nl)
C&L Inventory, Biocidal active substances
chlorcresol (da)
Biocidal active substances
chlorkresol (cs)
C&L Inventory, Biocidal active substances
Chlorkrezolis (lt)
C&L Inventory, Biocidal active substances
chlorocresol (da)
C&L Inventory, Biocidal active substances
Chlorocrésol (fr)
C&L Inventory, Biocidal active substances
Chlorokresol (de)
Biocidal active substances
chlórkrezol (sk)
C&L Inventory, Biocidal active substances
clor crezol (ro)
C&L Inventory
Clorocresol (es)
C&L Inventory, Biocidal active substances
Clorocresolo (it)
C&L Inventory, Biocidal active substances
Clorocrezol (ro)
Biocidal active substances
Hlorkrezols (lv)
C&L Inventory, Biocidal active substances
kloorikresoli (fi)
C&L Inventory
klorkresol (no)
C&L Inventory
Klorokresol (mt)
Biocidal active substances
Klorokresoli (fi)
Biocidal active substances
Klorokresool (et)
C&L Inventory, Biocidal active substances
Klorokrezol (hr)
C&L Inventory, Biocidal active substances
klórkrezol (hu)
C&L Inventory
χλωροκρεζόλη (el)
C&L Inventory
Χλωροκρεσόλη (el)
Biocidal active substances
Хлорокрезол (bg)
C&L Inventory, Biocidal active substances
Phenol, 4-chloro-3-methyl-
Other
4-Chlor- 3-methylphenol
C&L Inventory
4-chloro-3-methyl phenol
C&L Inventory
4-Chloro-m-cresol, PCMC, 2-Chloro-5-hydroxytoluene
Registration dossier
p-chloro-m-cresol
C&L Inventory
59-50-7
CAS number
EC Inventory, C&L Inventory, Biocidal active substances, Registration dossier, REACH pre-registration, Other, EU. Worker Protection-Hazardous (98/24), EU. Cosmetics Regulation Annex V, Allowed Preservatives, EU. Dangerous Substances - Eco-Labels, EU. Workplace Signs, EU. Hazardous Waste Properties: Annex III (2008/98/EC), EU. Young People at Work (94/33)
604-014-00-3
Index number
C&L Inventory

Scientific properties

Physical and chemical properties

This section provides physicochemical information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Appearance/physical state / colour

Study results
  • 6 studies submitted
  • 2 studies processed
C Physical state at 20°C and 1013 hPa
Solid (100%) [2]
C Form
Solid (50%), Solid: pellets (50%) [2]
C Odour
Other (100%) [3]
C Substance type
Organic (100%) [1]

Type of Study provided
Studies with data
Key study 1 1
Supporting study 4
Weight of evidence
Other
Data waiving
no waivers
C Summaries
  • 1 summary submitted
  • 1 summary processed
Physical state at 20°C and 1013 hPa
Solid (100%)

Melting/freezing point

Study results
  • 4 studies submitted
  • 2 studies processed
R Melting / freezing point
64.2 - 98.2 °C @ 97.5 kPa [2]

Type of Study provided
Studies with data
Key study 2
Supporting study 2
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Melting / freezing point at 101 325 Pa
102.05 °C

Boiling point

Study results
  • 4 studies submitted
  • 2 studies processed
R Boiling point
170.9 - 242 °C @ 97.5 - 101.325 kPa [2]

Type of Study provided
Studies with data
Key study 2
Supporting study 1 1
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Boiling point at 101 325 Pa
177.6 °C

Density

Study results
  • 4 studies submitted
  • 2 studies processed
R Density
0.709 g/cm³ @ 30 °C [1]
R Relative density
1.335 @ 20 °C [1]

Type of Study provided
Studies with data
Key study 2
Supporting study 2
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Relative density at 20°C
0.472

Vapour pressure

Study results
  • 4 studies submitted
  • 1 study processed
R Vapour pressure
0.077 - 2.29 Pa @ 20 - 50 °C [3]

Type of Study provided
Studies with data
Key study 2
Supporting study 2
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Vapour pressure
6.66 Pa @ 20 °C

Partition coefficient

Study results
  • 5 studies submitted
  • 2 studies processed
R Log Pow
0.477 - 2.73 @ 25 - 30 °C and pH 5.03 - 7.2 [2]

Type of Study provided
Studies with data
Key study 2
Supporting study 2 1
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Log Kow (Log Pow)
0.477 @ 30 °C

Water solubility

Study results
  • 4 studies submitted
  • 2 studies processed
R Water solubility (mass/vol.)
3.3 - 4.1 g/L @ 20 - 30 °C and pH 5 - 8.8 [5]

Type of Study provided
Studies with data
Key study 2
Supporting study 2
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Water solubility
4 g/L @ 30 °C

Solubility in organic solvents / fat solubility

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other 1
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Surface tension

Study results
  • 2 studies submitted
  • 1 study processed
R Surface tension
61.49 mN/m @ 1 g/L and 20 °C [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Flash point

Study results
  • 2 studies submitted
  • 1 study processed
R Flash point
81.1 °C @ 97.5 kPa [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
Not feasible 1
Sci. unjustified
Exposure cons.
Other
R Summaries
  • 1 summary submitted
  • 1 summary processed
Flash point at 101 325 Pa
84.28 °C

Auto flammability

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 2
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Flammability

Study results
  • 5 studies submitted
  • 3 studies processed
C Interpretation of results
Not classified based on GHS criteria (67%), Non flammable (33%) [3]

Type of Study provided
Studies with data
Key study 3
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other
C Summaries
  • 1 summary submitted
  • 1 summary processed
Flammability
Non flammable (100%)

Explosiveness

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other
C Summaries
  • 1 summary submitted
  • 1 summary processed
Explosiveness
Non-explosive (100%)

Oxidising

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
C Summaries
  • 1 summary submitted
  • 1 summary processed
Oxidising
Yes (100%)

Oxidation reduction potential

Data not provided by the registrant

pH

Study results
  • 4 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other 2
Data waiving
no waivers

No summary exists for this scientific endpoint

Dissociation constant

Study results
  • 3 studies submitted
  • 2 studies processed
C Dissociating properties
Yes (50%), Ambiguous (50%) [2]
R Dissociation constant
0 - 9.4 @ 20 - 30 °C [4]

Type of Study provided
Studies with data
Key study 2
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
pKa at 20 °C
0

Viscosity

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible 1
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Environmental fate and pathways

This section provides environmental fate and pathways information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Phototransformation in air

Study results
  • 1 study submitted
  • 1 study processed
R Degradation rate constant (OH radicals)
0 cm³ molecule-1 d-1 [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Half life in air
14.88 h

Hydrolysis

Study results
  • 2 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 1 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Half-life for hydrolysis
4.998 h @ 25 °C

Phototransformation in water

Data not provided by the registrant

Phototransformation in soil

Data not provided by the registrant

Biodegradation in water - screening tests

Study results
  • 7 studies submitted
  • 4 studies processed
C Interpretation of results
Readily biodegradable (50%), Under test conditions no biodegradation observed (50%) [4]

Type of Study provided
Studies with data
Key study 3 1
Supporting study 2 1
Weight of evidence
Other
Data waiving
no waivers
C Summaries
  • 1 summary submitted
  • 1 summary processed
Biodegradation in water
Readily biodegradable (100%)

Biodegradation in water & sediment - simulation tests

Study results
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Half-life in freshwater
37.5 days @ 25 °C
Half-life in freshwater sediment
11.25 months @ 25 °C

Biodegradation in soil

Study results
  • 1 study submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Half-life in soil
75 days @ 25 °C

Bioaccumulation: aquatic / sediment

Study results
  • 3 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 1 1
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Bioaccumulation: terrestrial

Data not provided by the registrant

Adsorption/desorption

Study results
  • 4 studies submitted
  • 2 studies processed
R Koc
158.5 - 508.2 L/kg @ 20 - 40 °C and 1.2 - 3.3 % organic carbon [5]
R log Koc
2.2 dimensionless @ 40 °C [1]
R Kd
1.9 - 11.8 L/kg @ 20 °C and 1.2 - 3.3 % organic carbon [4]

Type of Study provided
Studies with data
Key study 3 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Koc at 20°C
393.44

Henrys law constant (H)

Study results
  • 1 study submitted
  • 1 study processed
R H - (pressure) m³/mol
0.061 Pa m³/mol @ 25 °C [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Henry's law constant
0.061 Pa.m³.mol-1 @ 25 °C

Distribution modelling

Data not provided by the registrant

Ecotoxicological information

This section provides ecotoxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Predicted No-Effect Concentration (PNEC)

R Summaries
  • 1 summary submitted
  • 1 summary processed

The Predicted No-Effect Concentration (PNEC) value is the concentration of a substance below which adverse effects in the environment are not expected to occur. Please note that when more than one summary is provided, PNEC values may refer to constituents of the substance and not to the substance as a whole. More detailed information is available in the dossiers.

Hazard for Aquatic Organisms
Freshwater 15 µg/L (1)
Intermittent releases (freshwater) 15 µg/L (1)
Marine water 1.5 µg/L (1)
Intermittent releases (marine water) -
Sewage treatment plant (STP) 2.286 mg/L (1)
Sediment (freshwater) 13.981 mg/kg sediment dw (1)
Sediment (marine water) 13.981 mg/kg sediment dw (1)
Hazard for Air
Air No hazard identified (1)
Hazard for Terrestrial Organism
Soil 6.399 mg/kg soil dw (1)
Hazard for Predators
Secondary poisoning No potential for bioaccumulation (1)

Short–term toxicity to fish

Study results
  • 5 studies submitted
  • 3 studies processed
P/RResults
LC50 (4 days) 917 - 7 560 µg/L [3]
NOEC (4 days) 366 µg/L [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence 4
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
LC50 for freshwater fish
6.71 mg/L

Long–term toxicity to fish

Study results
  • 3 studies submitted
  • 1 study processed
P/RResults
NOEC (28 days) 150 µg/L [1]
LOEC (28 days) 500 µg/L [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Short–term toxicity to aquatic invertebrates

Study results
  • 5 studies submitted
  • 3 studies processed
P/RResults
EC50 (48 h) 1.5 - 2.29 mg/L [2]
LC50 (48 h) 2 - 3.9 mg/L [2]
NOEC (48 h) 1.73 mg/L [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence 3
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
EC50 / LC50 for freshwater invertebrates
2 mg/L

Long–term toxicity to aquatic invertebrates

Study results
  • 3 studies submitted
  • 1 study processed
P/RResults
NOEC (21 days) 320 - 1 000 µg/L [2]
LOEC (21 days) 1 mg/L [2]

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to aquatic algae and cyanobacteria

Study results
  • 4 studies submitted
  • 3 studies processed
P/RResults
EC50 (4 days) 10 mg/L [1]
EC50 (72 h) 14.72 - 30.62 mg/L [4]
NOEC (72 h) 1.9 - 9.8 mg/L [4]
LOEC (72 h) 5.7 mg/L [1]
EC10 (4 days) 5.2 mg/L [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence 2
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
EC50 for freshwater algae
15 mg/L
EC10 or NOEC for freshwater algae
1.9 mg/L

Toxicity to aquatic plants other than algae

Data not provided by the registrant

Toxicity to microorganisms

Study results
  • 2 studies submitted
  • 1 study processed
P/RResults
EC50 (3 h) 41.4 mg/L [1]
EC10 (3 h) 5.7 mg/L [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence 1
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
EC50 for microorganisms
22.86 mg/L

Sediment toxicity

Data not provided by the registrant

Endocrine disrupter testing in aquatic vertebrates – in vivo

Data not provided by the registrant

Toxicity to terrestrial macroorganisms except arthropods

Study results
  • 3 studies submitted
  • 1 study processed
P/RResults
NOEC (56 days) 10 mg/kg soil dw [1]
NOEC (28 days) 40 - 80 mg/kg soil dw [2]
LOEC (56 days) 20 mg/kg soil dw [1]
LOEC (28 days) 80 mg/kg soil dw [2]
EC50 (56 days) 40.9 mg/kg soil dw [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to terrestrial arthropods

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to terrestrial plants

Study results
  • 3 studies submitted
  • 2 studies processed
P/RResults
NOEC (46 days) 100 - 200 mg/kg soil dw [2]
NOEC (35 days) 100 - 200 mg/kg soil dw [2]
NOEC (14 days) 2.4 - 100 mg/kg soil dw [5]
NOEC (7 days) 100 - 200 mg/kg soil dw [2]
LOEC (46 days) 200 mg/kg soil dw [1]

Type of Study provided
Studies with data
Key study 3
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to soil microorganisms

Study results
  • 3 studies submitted
  • 1 study processed
P/RResults
NOEC (3.333 months) 30 mg/kg soil dw [1]
NOEC (28 days) 300 mg/kg soil dw [1]
EC50 (3.333 months) 395.1 mg/kg soil dw [1]
EC50 (28 days) 555.1 mg/kg soil dw [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to birds

Data not provided by the registrant

Toxicity to mammals

Data not provided by the registrant

Toxicological information

This section provides toxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Derived No- or Minimal Effect Level (DN(M)EL)

M/C Summaries
  • 1 summary submitted
  • 1 summary processed

The derived no- or minimum effect level (DN(M)EL) is the level of exposure above which a human should not be exposed to a substance. Please note that when more than one summary is provided, DN(M)EL values may refer to constituents of the substance and not to the substance as a whole. More detailed information is available in the dossiers.

Data for WORKERS
INHALATION Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 6.289 mg/m³ effect on fertility
Acute /short term: No hazard identified
Local Effects
Long-term: No hazard identified
Acute /short term: No hazard identified
DERMAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 3.567 mg/kg bw/day effect on fertility
Acute /short term: No hazard identified
Local Effects
Long-term: No hazard identified
Acute /short term: No hazard identified
EYE Exposure
Medium hazard (no threshold derived)
Data for the GENERAL POPULATION
INHALATION Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 1.551 mg/m³ effect on fertility
Acute /short term: No hazard identified
Local Effects
Long-term: No hazard identified
Acute /short term: No hazard identified
DERMAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 1.783 mg/kg bw/day effect on fertility
Acute /short term: No hazard identified
Local Effects
Long-term: No hazard identified
Acute /short term: No hazard identified
ORAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 891.667 µg/kg bw/day effect on fertility
Acute /short term: No hazard identified
EYE Exposure
Medium hazard (no threshold derived)

Toxicokinetics, metabolism, and distribution

Study results
Study data: basic toxicokinetics
  • 6 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: basic toxicokinetics
Studies with data
Key study 1
Supporting study 2
Weight of evidence 3
Other
Data waiving
no waivers
Study data: dermal absorption
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: dermal absorption
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Bioaccumulation potential:
Low bioaccumulation potential

Acute toxicity

Study results
oral
  • 6 studies submitted
  • 1 study processed
P/RResults
LD50 1 830 mg/kg bw (rat) [1]
M/CInterpretations of results
Category 4 based on GHS criteria [1]

Type of Study provided
oral
Studies with data
Key study 1
Supporting study 2
Weight of evidence 3
Other
Data waiving
no waivers
inhalation
  • 3 studies submitted
  • 1 study processed
P/RResults
LC50 (4 h) 2.86 - 3 mg/L air (rat) [3]
M/CInterpretations of results
Other [1]

inhalation
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
dermal
  • 5 studies submitted
  • 3 studies processed
P/RResults
LD50 2 000 - 5 000 mg/kg bw (rat) [4]
M/CInterpretations of results
Not classified [2]

dermal
Studies with data
Key study 1
Supporting study 2
Weight of evidence 2
Other
Data waiving
no waivers
other routes
  • 0 studies submitted
  • 0 studies processed

No data available

other routes
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Oral route:
No adverse effect observed LD50 5 129 mg/kg bw
Dermal route:
No adverse effect observed LD50 2 000 mg/kg bw

Irritation / corrosion

Study results
Study data: skin
  • 8 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: skin
Studies with data
Key study
Supporting study
Weight of evidence 6
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other 1
Study data: eye
  • 8 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: eye
Studies with data
Key study
Supporting study
Weight of evidence 6
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other 1
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Skin
Adverse effect observed (irritating)
Eye
Adverse effect observed (irritating)

Sensitisation

Study results
Study data: skin
  • 8 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: skin
Studies with data
Key study 1
Supporting study 2
Weight of evidence 3
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other 1
Study data: respiratory
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: respiratory
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Skin sensitisation
Adverse effect observed (sensitising)

Repeated dose toxicity

Study results
Study data: oral
  • 4 studies submitted
  • 2 studies processed
P/RResults
NOAEL (rat): 1 500 ppm [1]
NOEL (rat): 125 mg/kg bw/day [1]

Type of Study provided
Study data: oral
Studies with data
Key study 1
Supporting study
Weight of evidence 2 1
Other
Data waiving
no waivers
Study data: inhalation
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Study data: inhalation
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Study data: dermal
  • 3 studies submitted
  • 1 study processed
P/RResults
NOAEL (rat): 500 mg/kg bw/day [1]

Study data: dermal
Studies with data
Key study 1
Supporting study
Weight of evidence 2
Other
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Oral route - systemic effects:
No adverse effect observed NOAEL 200 mg/kg bw/day (subacute, rat)
Dermal route - systemic effects:
No adverse effect observed NOAEL 40 mg/kg bw/day (subacute, mouse)

Genetic toxicity

Study results
Study data: in vitro
  • 8 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: in vitro
Studies with data
Key study 3
Supporting study
Weight of evidence 4
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Study data: in vivo
  • 2 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: in vivo
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Toxicity - InVitro
No adverse effect observed (negative)

Carcinogenicity

Data not provided by the registrant

Toxicity to reproduction

Study results
Study data: reproduction
  • 5 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: reproduction
Studies with data
Key study 1
Supporting study
Weight of evidence 2 1
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Study data: developmental
  • 5 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: developmental
Studies with data
Key study 1
Supporting study
Weight of evidence 3 1
Other
Data waiving
no waivers
Study data: other studies
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: other studies
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Effect on fertility
Oral route:
No adverse effect observed NOAEL 30 mg/kg bw/day (subacute, rat)
Effect on developmental toxicity
Oral route:
No adverse effect observed NOAEL 30 mg/kg bw/day (subacute, rat)

Neurotoxicity

Data not provided by the registrant

Immunotoxicity

Data not provided by the registrant

Endocrine disrupter mammalian screening - in vivo

Data not provided by the registrant