Registration Dossier
Registration Dossier
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EC number: 223-362-3 | CAS number: 3855-32-1
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The study preceeds current OECD guidelines, however is equivalent to OECD Guideline 404 (Acute Dermal Irritation / Corrosion). No GLP, however the study is sufficiently reported and the results unambiguous.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 987
- Report date:
- 1987
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- not specified
- GLP compliance:
- no
- Test type:
- standard acute method
Test material
- Reference substance name:
- N-[3-(dimethylamino)propyl]-N,N',N'-trimethylpropane-1,3-diamine
- EC Number:
- 223-362-3
- EC Name:
- N-[3-(dimethylamino)propyl]-N,N',N'-trimethylpropane-1,3-diamine
- Cas Number:
- 3855-32-1
- Molecular formula:
- C11H27N3
- IUPAC Name:
- (3-{[3-(dimethylamino)propyl](methyl)amino}propyl)dimethylamine
- Test material form:
- gas under pressure: refrigerated liquefied gas
Constituent 1
Test animals
- Species:
- other: Rat and Mouse
Administration / exposure
- Route of administration:
- oral: drinking water
- Vehicle:
- water
- Control animals:
- no
Results and discussion
Effect levelsopen allclose all
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 2.37 mL/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: Male Rat
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- ca. 2.3 mL/kg bw
- Based on:
- test mat.
- 95% CL:
- >= 2.09 - <= 2.51
- Remarks on result:
- other: Female rat
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- ca. 2.19 mL/kg bw
- Based on:
- test mat.
- 95% CL:
- >= 1.97 - <= 2.46
- Remarks on result:
- other: Male Mouse
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- ca. 1.68 mL/kg bw
- Based on:
- test mat.
- 95% CL:
- >= 1.49 - <= 1.87
- Remarks on result:
- other: Female Mouse
- Mortality:
- Obsrved in all treated groups.
- Clinical signs:
- other: Decreased activity, ataxia, dyspnea and writhing
- Other findings:
- Signs of toxicity were observed immediately after treatment and jpersisted les than 24 hours post-treatment (corrosive)
Applicant's summary and conclusion
- Interpretation of results:
- moderately toxic
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Rat - Acute Oral Toxicity LD50 1598 mg/kg
The substance is severely irritating and corrosive to the skin and eyes. This material is irritating and corrosive to the nasal and respiratory tract
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