Registration Dossier
Registration Dossier
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EC number: 223-362-3 | CAS number: 3855-32-1
Bioaccumulation: aquatic / sediment
Administrative data
Link to relevant study record(s)
Description of key information
A study on the bioaccumulation of a supporting substance (N,N-bis[3-(dimethylamino)propyl]-N',N'-dimethylpropan-1,3-diamine; CASRN 33329-35-0) in fish was conducted in accordance with "Test method for new chemical substances" determined in Regulation Number 392 (1974), based upon read-across from a supporting substance (structural analogue or surrogate).
Key value for chemical safety assessment
- BCF (aquatic species):
- 2 dimensionless
Additional information
The experimentally-determined log Kow of 0 for the substance is substantially below the criterion of log Kow˂ 3 at which bioaccumulation testing is not indicated, as described in Regulation (EC) No.1907/2006, Annex IX, Column 2. In addition, the bioaccumulation study in carp of a supporting substance (N,N-bis[3-(dimethylamino)propyl]-N',N'-dimethylpropan-1,3-diamine; CASRN 33329-35-0) indicated that bioconcentration is not of concern; the BCF value ≤ 2 from the low concentration test and BCF ≤ 0.7 from the high concentration test are each substantially below the definitive criteria for both bioaccumulative (> 2,000 L/kg) and very bioaccumulative (>5,000 L/kg) substances, based upon read-across from a supporting substance (structural analogue or surrogate). Therefore, bioaccumulation is not expected in the aquatic compartment.
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