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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2006
Report date:
2006

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 402 (Acute Dermal Toxicity)
GLP compliance:
yes
Test type:
standard acute method
Limit test:
yes

Test material

Reference
Name:
Unnamed
Test material form:
liquid
Specific details on test material used for the study:
SOURCE OF TEST MATERIAL
- Purity : 96.7%

Test animals

Species:
rat
Strain:
Wistar
Sex:
male/female

Administration / exposure

Vehicle:
unchanged (no vehicle)
Details on dermal exposure:
App. 10% of the body surface area was clipped 24 hours prior to the dermal application.
Duration of exposure:
24 hrs exposure period and observation for a period of 14 days.
Doses:
2000 mg/kg b.w. by single dermal application of 0.41 to0.57 ml of undiluted test substance
No. of animals per sex per dose:
Two groups of rats, each comprising of 5 males and 5 females.
Control animals:
yes, concurrent vehicle
Details on study design:
The substance was held in contact with the skin throughout the 24 hours exposure period using a porous gauze dressing and a non-irritating tape

Results and discussion

Effect levels
Key result
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 2 000 mg/kg bw
Based on:
test mat.
Mortality:
No mortality was observed.
Clinical signs:
No clinical sign was observed.
Gross pathology:
Lesion that were observed in the rats sacrificed at termination belonging to the control group were considered to be spontaneous or incidental findings.

Applicant's summary and conclusion

Interpretation of results:
Category 5 based on GHS criteria
Conclusions:
The acute dermal median lethal dose LD50 (cut off value) of d-trans Allethrin 75/25 in Wistar rats was found to be greater than 2000 mg/kg b.w.